Time-dependent effects of oral morphine on autotomy following brachial nerve section in the rat. |
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| Authors: | T Yamamoto T Mizuguchi |
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| Affiliation: | Department of Anesthesiology, School of Medicine, Chiba University, Japan. |
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| Abstract: | In this study, the effects of morphine in drinking water on autotomy in male F344 rats having undergone brachial nerve sections were assessed during a 3-week period. Morphine was self-administered orally in tap water by the rats. Rats administered morphine just after the nerve section or 1 week after the nerve section showed a significant increase in the severity of autotomy when compared to the rats administered distilled water. Morphine had no effect on autotomy when it was administered 2 weeks after the nerve section. These results suggested that the effect of oral morphine on autotomy changes in a time-dependent manner. |
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