The T-cell antigen receptor gamma gene: rearrangement and cell lineages |
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| Affiliation: | 1. Cancer Research Laboratory, Department of Microbiology and Immunology, University of California, Berkeley, California 94720, USA;2. Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043, USA |
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| Abstract: | Most adult T cells have a T-cell antigen receptor composed of αß heterodimers in a complex with the CD3 antigen. Immature thymocytes, however, can express CD3-associated heterodimers of a γ chain and another poorly characterized chain (‘δ’). Here James Allison and Lewis Lanier suggest that thymocytes can develop along two mutually exclusive ontological pathways, giving rise to T cells that express either αß or γδ heterodimers, but not both or any other heterodimeric combination. |
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