Regulation of hormone-sensitive adenylate cyclase |
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| Affiliation: | 1. Department of Chemistry and Biochemistry, The City College of New York, New York, NY 10031, USA;2. Division of Chemical Biology and Medicinal Chemistry, The University of Texas, Austin, TX 78712, USA;3. The Graduate Center of The City University of New York (CUNY), New York, NY 10016, USA;1. Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA;1. Rudolf Boehm Institute of Pharmacology and Toxicology, Medical Faculty, Leipzig University, 04107 Leipzig, Germany;2. Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA;3. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA;4. Department of Pharmacology, University of Washington Medical Center, Seattle, WA 98195, USA |
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| Abstract: | Adenylate cyclases in the membranes of eukaryotes are regulated by stimulatory receptors (Rs) and inhibitory receptors (Ri) which activate the catalyst adenylate cyclase (C) through the heterotrimeric GTP-binding proteins, Gs and Gi. The actions of Gs and Gi are not symmetric, since Gs associates tightly with C, whereas Gi does not. Alexander Levitzki analyses the current knowledge and thinking on the mode of interaction between each of these regulatory units and describes one working model which accounts for all the experimental observations and the kinetics involved. |
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