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Electrophysiological studies of NMDA receptors
Institution:1. Laboratoire de Neurobiologie, Ecole Normale Supérieure, 46 rue d''Ulm, 75005 Paris, France;2. Department of Pharmacology, NYS Veterinary College, Cornell University, Ithaca, NY 14853, USA.;1. Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, United States;2. Departments of Psychiatry, Neuroscience & Physiology, and the NYU Neuroscience Institute, New York University School of Medicine, New York, NY, 10016, United States;3. Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239, United States;4. VA Portland Health Care System, Portland, OR, 97239, United States;5. Department of Psychiatry, Columbia University Medical Center, New York, NY, 10032, United States;6. Department of Psychiatry, New York University School of Medicine, New York, NY, 10016, United States;1. Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA;2. Neurobiology Curriculum, University of North Carolina, Chapel Hill, NC 27599, USA;3. UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA;4. Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC 27599, USA;1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;2. School of Life Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;3. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;4. Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110840, People’s Republic of China
Abstract:Recent electrophysiological studies of NMDA receptors and of the associated ion channels (NMDA channels) have revealed five properties of this system: (1) the NMDA channels are blocked by Mg2+ in a voltage-dependent way; (2) the NMDA channels are permeable to Ca2+ as well as to Na+ and K+; (3) the NMDA channels may adopt multiple conductance states; some of the minor states (small conductances) resemble the major conductance states opened by non-NMDA agonists; (4) continued exposure to NMDA agonists produces short-term and long-term decreases in the sensitivity of the NMDA system; and (5) glycine potentiates the response to NMDA.
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