| 血液透析中肝素用量监测的临床应用研究 |
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| 引用本文： | 陈玉珍,屈燧林,刘定远,李建国,陈启光. 血液透析中肝素用量监测的临床应用研究[J]. 四川大学学报(医学版), 1996, 0(3) |
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| 作者姓名： | 陈玉珍 屈燧林 刘定远 李建国 陈启光 |
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| 摘 要： | 根据Ｇｏｔｃｈ的肝素动力学模型，作者设计出逐段线性加权新模型，以计算肝素的消除速率常数（Ｋ）。用该模型对２６例血液透析（ＨＤ）肝素用量不稳定患者，在袖珍计算机床旁监控下进行了１００例次ＨＤ。基本上达到了ＨＤ中稳态的抗凝效果，并且避免了ＨＤ中患者出血，透析器和血液管道凝血等并发症。作者所设计的计算框图便于采用不同的计算机语言编制程序，以指导ＨＤ中肝素使用
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| 关 键 词： | 肝素 药物动力学 消除速率常数 血液透析 |
Study Clinical Application to Determine Heparin Requirements During Hemodialysis |
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| Chen Yuzhen Qu Suilin Liu Dingyuan Li Jianguo Chen Qiguang. Study Clinical Application to Determine Heparin Requirements During Hemodialysis[J]. Journal of Sichuan University. Medical science edition, 1996, 0(3) |
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| Authors: | Chen Yuzhen Qu Suilin Liu Dingyuan Li Jianguo Chen Qiguang |
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| Affiliation: | Chengdu 610041 |
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| Abstract: | A de nove Weighted Stepwise Linear Model based on Gotch's heparin pharmacokinetic mo del has been designed to determine the heparin elimination rate constant during hemodialysis (HD). 100 times of HD in 26 patients with unstable dosage requirements of heparin were performed according to the computing method and the new heparin pharmacokinetic Weighted Stepwise Linear Model monitored by program of pocket calculator. The results showed not only stable anticoagulation but also successful prevention of patients's bleeding and avoidance of coagulation in hemodialyzer and blood tubing. The computer diagram presented in this paper is useful for propramming with different computer languages to calculate the heparin dosage requirements of patients undergoing HD. |
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| Keywords: | Heparin Pharmacokinetics Elimination rate constant Hemodialysis |
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