经皮肝穿刺活检确诊无症状原发性肝结核一例

本文报告一例患者,女性,18岁,无任何临床症状和体征,纯化蛋白衍生物结核菌素试验强阳性,经B超发现肝右叶钙化灶,2年后发现肝内多发占位,经皮肝活检病理学检查发现干酪样肉芽肿,诊断为无症状原发性肝结核,抗结核(异烟肼、乙胺丁醇和利福平)治疗2个月后肝内病灶缩小.原发性肝结核可以没有临床症状,单纯表现为肝内钙化灶;肝穿刺活检病理检查是确诊的有效手段;无症状原发性肝结核应抗结核治疗.

A case of asymptomatic primary liver tuberculosis proven by percutaneous liver biopsy

The patient, an 18-year-old girl, was found to have strong positive purified protein derivative of tuberculin (PPD) test and calcified focus in her liver 2 years ago. She denied fever, cough, sputum, weight loss, night sweats, fatigue, and anorexia. After admission, physical examination, laboratory tests, CXR, abdominal CT, colonoscopy and gynecological examination were all normal except for the liver lesions. Percutaneous needle biopsy was performed under sonographic guidance and pathological examination showed caseous granuloma. She was diagnosed as primary liver tuberculosis and the lesions decreased after 2 months' therapy of isoniazid, rifampicin and ethambutol. Primary liver tuberculosis could be asymptomatic and manifestated as calcified focus; percutaneous needle biopsy and pathological examination is helpful for the diagnosis. The asymptomatic liver lesions are still an indication for anti-tuberculosis therapy.