The Role of Colonic Microbiota in Lactose Intolerance |
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Authors: | Yan Zhong Marion G Priebe Roel J Vonk Cheng-Yu Huang Jean-Michel Antoine Tao He Hermie J M Harmsen Gjalt W Welling |
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Institution: | Huaxi School of Public Health, Sichuan University, Chengdu, PR China. |
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Abstract: | In a previous study we observed a clear difference in lactose intolerance symptoms after a 25-g lactose load in two groups of persons with lactase nonpersistence and similar small intestinal lactase activity. From this observation we hypothesized a colon resistance factor. To identify this factor, the microbial composition of fecal samples of the two lactose intolerant groups (one with mild symptoms, n = 16, and one with diarrhea-predominant symptoms, n = 11) was compared using the fluorescent in situ hybridization technique. Large interindividual differences were found in the numbers of total bacteria and main groups of bacteria (CV: 0.65 and 0.64-0.82 respectively). The bacterial numbers were not significantly different between the two groups. A significant negative correlation, however, was found between the individual symptom scores of the intolerant persons and the numbers of total hybridizable bacteria (r(s) = -0.42, P = 0.03). The results suggest that an increased number of bacteria might contribute--by means of a higher fermentative capacity--to the reduction of lactose intolerance symptoms. |
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Keywords: | lactose intolerance colonic microbiota fluorescent in situ hybridization |
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