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The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS
Authors:Lichterfeld Mathias  Nischalke Hans Dieter  van Lunzen Jan  Söhne Jennifer  Schmeisser Norbert  Woitas Rainer  Sauerbruch Tilman  Rockstroh Jürgen K  Spengler Ulrich
Institution:1. Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universität Bonn, Bonn, Germany;2. Zentrum für Innere Medizin, Medizinische Klinik I, Universitätsklinikum Eppendorf, Hamburg, Germany
Abstract:DC-SIGNR is a C-type lectin that functions as a transreceptor for HIV-1. The exon 4 of the DC-SIGNR gene comprises a variable number of 69-bp tandem repeats, encoding for parts of the extracellular protein domain. Here, we analyzed the relevance of this gene polymorphism for the interindividual transmission of HIV-1 and the progression to AIDS. A cross-sectional comparison between HIV-1-infected patients (n = 391) and healthy volunteers (n = 134) did not reveal significant differences with regard to the DC-SIGNR allele distribution. Moreover, DC-SIGNR allele frequencies were similar in slowly progressing HIV patients (n = 31) and patients who rapidly progressed to AIDS (n = 46). Additionally, in a cohort of 149 newly HIV-infected patients, no relationship was found between HIV set point viremia and DC-SIGNR genotypes. Thus, the DC-SIGNR tandem-repeat polymorphism in exon 4 does not have a significant impact on the host's susceptibility to HIV and the clinical progression to AIDS.
Keywords:HIV-1  DC-SIGNR  CD209L  Genetic polymorphisms  Transreceptor
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