| 吡格列酮治疗2型糖尿病合并非酒精性脂肪肝病的临床观察 |
| |
| 引用本文： | 黄文森.吡格列酮治疗2型糖尿病合并非酒精性脂肪肝病的临床观察[J].辽宁医学院学报,2010,31(2):128-130. |
| |
| 作者姓名： | 黄文森 |
| |
| 作者单位： | 泉州医学高等专科学校内科学教研室,福建,泉州362000 |
| |
| 摘 要： | 目的探讨吡格列酮对2型糖尿病合并非酒精性脂肪肝病的临床效果。方法45例初诊的2型糖尿病合并非酒精性脂肪肝病患者随机分为两组:吡格列酮组给予盐酸吡格列酮片30mg,每日1次;对照组给予除噻唑烷二酮类及双胍类以外的降糖药物治疗,疗程6个月。观察分析两组治疗前后的空腹血糖、餐后2小时血糖、糖基化血红蛋白、空腹血胰岛素、胰岛素抵抗指数、血脂、肝功能及脂肪肝的变化情况。结果两组均可显著降低空腹血糖、餐后2小时血糖、糖基化血红蛋白,两组相比无统计学意义(P>0.05)。吡格列酮组在降低空腹血胰岛素、胰岛素抵抗指数及改善肝功能、血脂、脂肪肝程度方面,与对照组相比均有统计学意义(P<0.05)。结论吡格列酮具有减少胰岛素抵抗、改善脂肪肝的作用,是治疗2型糖尿病合并非酒精性脂肪肝病的理想选择。
|
| 关 键 词： | 吡格列酮 2型糖尿病 非酒精性脂肪肝病 |
Clinical Observation of Pioglitazone in the Treatment of Non-alcoholic Fatty Liver Disease with Type 2 Diabetes Mellitus |
| |
| HUANG Wensen.Clinical Observation of Pioglitazone in the Treatment of Non-alcoholic Fatty Liver Disease with Type 2 Diabetes Mellitus[J].Journal of Liaoning Medical University (LNMU) Bimonthly,2010,31(2):128-130. |
| |
| Authors: | HUANG Wensen |
| |
| Institution: | Department of Medicine of Advanced Quanzhou Medical Academy/a>;Quanzhou 362000 China |
| |
| Abstract: | Objective To explore the effects of Pioglitazone in Treatment of non-alcoholic fatty liver disease with type 2 diabetes mellitus.Methods 45 patients who were diagnosed non-alcoholic fatty liver disease with type 2 diabetes mellitus were randomly divided into two groups: Pioglitazone group with pioglitazone 30 mg once a day,while control group with Hypoglycemic drug except for Thiazolidine dione and Biguanides,the period of treatment is 6 months.Then the changes of fasting blood sugar,2-hour postprandial blo... |
| |
| Keywords: | pioglitazone type 2 diabetes mellitus non-alcoholic fatty liver disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
