| 乙型肝炎病毒e抗原结构、功能及变异的临床意义 |
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| 引用本文： | 张敏,辛绍杰,貌盼勇. 乙型肝炎病毒e抗原结构、功能及变异的临床意义[J]. 国际流行病学传染病学杂志, 2007, 34(1) |
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| 作者姓名： | 张敏 辛绍杰 貌盼勇 |
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| 作者单位： | 100039,北京,解放军第三○二医院传染病研究所 |
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| 摘 要： | HBeAg并非HBV装配、复制或感染所必需,但却具有免疫调节和影响病毒复制的重要功能,而HBeAg变异后出现的HBeAg阴性慢性乙型肝炎更有特殊的临床特征。此文就近年有关HBeAg结构及功能的研究进展及其变异临床意义进行综述。
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| 关 键 词： | 乙型肝炎病毒 抗原 功能 变异 |
Structure, function of hepatitis B virus e antigen and the clinical significance after HBeAg mutation |
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| ZHANG Min,XIN Shao-jie,MAO Pan-yong. Structure, function of hepatitis B virus e antigen and the clinical significance after HBeAg mutation[J]. International Journal of Epidemiology and Infectious Disease, 2007, 34(1) |
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| Authors: | ZHANG Min XIN Shao-jie MAO Pan-yong |
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| Abstract: | HBeAg is not essential for assembly,replication or infectivity of HBV,but is realized to play an important role on immune regulation and virus replication.After HBeAg mutation and disappearance in serum,HBeAg-negative chronic hepatitis B(CHB) shows different clinical character from HBeAg-positive CHB.Here we summarize the recent researches on structure,function of HBeAg as well as the clinical significance of CHB after HBeAg mutation. |
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| Keywords: | Hepatitis B virus Antigen Function Mutation |
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