| 多元凹面换能器聚焦超声系统损伤离体牛肝的实验研究 |
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| 引用本文： | 尹振宇,孔炜伟,刘宝瑞.多元凹面换能器聚焦超声系统损伤离体牛肝的实验研究[J].实用临床医药杂志,2005,9(5):14-16,20. |
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| 作者姓名： | 尹振宇 孔炜伟 刘宝瑞 |
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| 作者单位： | 南京大学医学院附属鼓楼医院,肿瘤中心,江苏,南京,210008;南京大学医学院附属鼓楼医院,肿瘤中心,江苏,南京,210008;南京大学医学院附属鼓楼医院,肿瘤中心,江苏,南京,210008 |
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| 基金项目： | 江苏省卫生厅重点资助项目(H200349) |
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| 摘 要： | 目的评价多元凹面换能器聚焦超声系统的有效性和安全性,为临床应用提供基础研究资料。方法在不同治疗剂量条件下,以该聚焦超声系统定点辅照离体牛肝,测定焦点温升及辅照后凝固性坏死体积,观察比较治疗前后靶区域超声灰度和病理变化。结果辅照后靶点温升可达80℃以上;随治疗剂量增大凝固性坏死长径和直径增大,体积增大;靶区超声灰度明显增强;光镜下见损伤区组织呈凝固性坏死,损伤区与正常组织分界清晰。结论该系统能有效地损伤靶点组织,使之发生凝固性坏死;并且辐照区域与周围组织分界清晰,诊断探头可实时监控靶点的灰度变化,具有良好的治疗安全性。
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| 关 键 词： | 聚焦超声 升温 生物学焦域 |
| 文章编号： | 1672-2353(2005)05-0014-03 |
| 修稿时间： | 2005年3月29日 |
EXPERIMENTAL STUDY OF ABLATION OF BOVINE LIVER TISSUE IN VITRO WITH MULTI-UNIT TRANSDUCER FOCUSED ULTRASOUND SYSTEM |
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| YIN Zhen-yu,KONG Wei-wei,LIU Bao-rui.EXPERIMENTAL STUDY OF ABLATION OF BOVINE LIVER TISSUE IN VITRO WITH MULTI-UNIT TRANSDUCER FOCUSED ULTRASOUND SYSTEM[J].Journal of Clinical Medicine in Practice,2005,9(5):14-16,20. |
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| Authors: | YIN Zhen-yu KONG Wei-wei LIU Bao-rui |
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| Abstract: | Objective To evaluate the efficacy and safety of Multi-unit Transducer Focused Ultrasound System. Methods Samples of bovine liver were ablated by various doses. Volume of coagulative necrosis, temperature rise of the focus, Ultrasound gray scale and pathological changes were recorded and compared. Results Temperature rise up to 80 ℃ can be acquired at the ablated area. Clear demarcation separating the necrosis and the normal tissues were observed. Conclusion The Multi-unit Transducer Focused Ultrasound System can effectively ablate the targeted area. Real time assessment of the gray scale changes of the targeted area can be acquired by the ultrasound probe. |
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| Keywords: | focused ultrasound temperature rise biological focal region |
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