血清尿酸水平对CRT治疗DCM预后的影响

目的:分析血清尿酸水平与经心脏再同步化治疗(CRT)扩张型心肌病(DCM)患者预后的关系。方法:回顾性分析2002年1月至2011年1月于我院进行CRT治疗的DCM患者的临床资料。根据手术前血清尿酸(UA)水平分为A,B两组。A组UA<420μmol;B组UA≥420μmol。分析各组患者的性别、年龄等基本资料。记录患者手术前、术后8个月的心功能分级、6min步行距离、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、二尖瓣返流量(MR)、死亡率及临床症状变化。并将数据进行分析。结果:尿酸正常的组心功能分级优于尿酸高的组(P<0.05),尿酸高的一组BNP恢复较尿酸正常组程度低(P<0.05),LVEF升高也低于尿酸正常组(P<0.05)。症状改善也较尿酸正常组低。结论:患者术前UA水平影响DCM患者经CRT治疗后的疗效。术前UA水平越高术后患者心功能恢复越差。

Levels of Serum Uric Acid on the Prognosis of CRT Treatment of DCM

Objective:Analysis the Relationship of prognosis between the serum uric acid levels and the dilated cardiomyopathy(DCM) patients after cardiac resynchronization therapy.Methods:Retrospective analysis from January 2002 to January 2011 in our hospital for treatment of patients with DCM CRT clinical data.According to pre-operative serum uric acid(UA) levels are divided into A,B groups.A group of UA <420μmol;B group UA ≥ 420μmol.Analysis of the group of patients with gender,age and other basic information.Record the patient before surgery,after 8 months of cardiac function,6min walking distance,left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),mitral valve back flow(MR),mortality and clinical symptoms.And data analysis.Results:Uric acid in normal cardiac function better than the group with high uric acid group(P <0.05),high uric acid group compared with uric acid in the normal group,BNP to restore low levels.LVEF increased also lower than in group A(P <0.05).Symptoms are more A low.Conclusion:Preoperative UA levels affect the efficacy of patients with DCM of CRT after treatment.The higher the level of preoperative UA patients after heart function worse.