缺氧缺血性脑病患儿血常规结果分析及其临床意义

目的探讨27项血常规参数在新生儿缺氧缺血性脑病（HIE）中的变化及其意义。方法利用全自动血细胞分析仪对29例HIE患儿和30例健康新生儿进行白细胞、红细胞及血小板等参数检测，分析其结果和临床意义。结果H1E组与对照组比较，（1）白细胞参数：淋巴细胞比率、单核细胞比率、中性粒细胞比率差异有统计学意义（P〈0．05），而白细胞计数、嗜酸性粒细胞比率、嗜碱性粒细胞比率差异无统计学意义（P〉0．05）；（2）红细胞参数：血细胞比容、红细胞平均体积、平均血红蛋白浓度（MCHC）、红细胞分布宽度CV、红细胞分布宽度SD、网织红细胞计数、网织红细胞百分比、未成熟网织红细胞、低荧光网织红细胞比率、高荧光网织红细胞比率、有核红细胞计数、有核红细胞百分比等12项红细胞参数差异有统计学意义（P〈0．05），而红细胞计数、血红蛋白、平均血红蛋白含量、中荧光强度网织红细胞比率等参数差异无统计学意义（P〉0．05）；（3）血小板参数：血小板计数、血小’板：压积差异有统计学意义（P〈0．05），而平均血小板体积、血小板分布宽度及大型血小板比率等参数差异无统计学意义（P〉0．05）。结论利用全自动血细胞分析仪对HIE患儿外周血进行常规筛查和动态监测，计数快速、准确，能很好地满足临床应用，协助临床诊断HIE。

Analysis of the blood routine tests results and its clinical implications in patients with hypoxicischemic encephalopathy

Objective To discuss the changes of blood routine＇s 27 parameters in neonatal hypoxic-ischemic encephalopathy （HIE） and implications. Methods We used Sysmex XE-5000 automatic blood cell analyzer to analyze the leukocyte,erythrocyte and platelet parameters of 29 HIE patients and 30 normal newborn babies. We analyzed the results and their clinical implications. Results Compared with normal newborn babies,in HIE patients, （1）the leukocyte parameter of lymphocyte ratio, monocyte ratio, neutro- phil ratio were significantly different（P~0.05） ,whereas the white blood cell count , eosinophil ratio, basophils ratio were not sig- nificantly different（P~0.05）. 12 erythrocyte parameter including hematocrit, mean corpuscular volume,mean hemoglobin concen- tration. （2）Red blood cell distrihution width CV, red blood cell distrihution width SD, reticulocyte count, percentage of reticulo- cytes,immature reticulocyte,low fluorescence reticulocyte fraction, high fluorescence reticulocyte fraction, nucleated red blood cell count,percentage of nucleated red blood cell were significantly different（P~0.05）. Whereas red blood cell count, hemoglobin, the average hemoglobin content,ratio of the median fluorescence reticulocytes were not significantly different（P〉0.05）. （3）Among platelet parameters, platelet count ,platelet hematocrit were significantly different（P《0.05）. Whereas mean platelet volume, plate- let distribution width and large platelet ratio were not significantly different（P〉0.05）. Conclusion Using Sysmex XE-5000 auto- matic blood analyzer to screen and monitor HIE patients peripheral blood is fast and accurate. It can meet the demand of clinical practice and assist the diagnosis of HIE.