不同糖化血红蛋白水平的2型糖尿病患者血液流变学检测分析

目的分析糖化血红蛋白（GHbAlc）控制在不同水平的2型糖尿病患者血液流变学的特点，为其治疗及预防提供参考依据。方法选取2型糖尿病病例113例，按GHbAlC不同水平分为：A组（33例，控制良好）、B组（40例，控制一般）、C组（40例，控制不佳）。同时随机抽取健康体检者40例作为对照（D组）。分别检测GHbAlC、血液流变学及生化指标，并进行分析对比。结果单因素方差分析显示，血流变相关指标除血细胞比容在四组之间无统计学意义外（F=0．08，P=0．970），其他指标在四组之间均存在统计学差异（P〈0．05）；采用LSD-t检验方法分析结果：血流变指标除血细胞比容外A、B、c组均明显高于D组（P〈0．05）；采用sN-K检验方法进行组闯分析：除全血高切、中切黏度、血沉方程K值A、C组比较，差异无统计学意义（P〉0．05）；血浆黏度、RBC刚性指数A、D组间比较，差异无统计学意义（P〉0．05）；RBC变形指数及三酰甘油B、C组间比较，差异无统计学意义（P〉0．05），余下各指标不同组之间的比较差异均有统计学意义（P〈0．05）。结论2型糖尿病患者存在血液流变学指标异常，不同GHbAlc水平下血液流变学指标有差异。

Analysis of hemorheology in type 2 diabetes patients of different glycosylated hemoglobin level

Objective To analyze the hemorheology of patients with type 1I diabetes in different glycosylated hemoglobin levels. Methods According to different levels of GHbAlc 116 patients with 2 diabetes were divided into good control A group of 33 cases, general control B group of 40 cases,and poor control C group of 40 cases from May 2010 to May 2012 in our community. At the same time healthy subjects were selected randomly as control D group of 40 cases. Hemorheology, GHbAlc and biochemical indexes were determined and analyzed. Results There were significant differences between the four groups in other index （P〈0.05） ex- cept hematoerit in hetween the four groups （F= 0.08, P = 0. 970）. The blood theological indexes except hematocrit were signifi- cantly higher than those in group D. Groups difference were analyzed with S-N-K test method and the results showed that there were no significant differences between A and C groups in whole blood high shear viscosity and moderate shear viseosity（P = 0. 345 ,P=O. 329）. So was that of ESR equation K value （P=0. 810）. No significant difference has been found between groups A and D in plasma viscosity and RBC rigidity index （P = 0. 396, P = 0. 507）. The remaining indexes were different between groups each other （P〈0.05）. Conclusion There are abnormal hemorheology indices in patients with type 2 diabetes mellitus and blood rheology index of different glycosylated hemoglobin levels are different.