慢性阻塞性肺疾病患者幽门螺杆菌感染的研究

目的探讨幽门螺杆菌（helicobacter pylori，Hp）感染与COPD的关系及在其发病机制中的作用。方法对52例COPD急性加重期患者（急性加重期组），35例稳定期患者（稳定期组）和22名正常对照者（正常对照组）进行肺功能测定、尿素13C呼气试验检测及血常规、C反应蛋白（CRP）的检测。结果COPD急性发作期组、稳定期组和正常对照组Hp阳性率分别为51．9％、45．1％和18．1％。急性加重期组与稳定期组Hp阳性率差异无统计学意义（P〉0．05），但与正常对照组比较，差异有统计学意义（P〈0．01）。COPD急性发作期组Hp阳性患者的FEV1％pred和FEV1／FVC水平明显低于阴性组，白细胞水平、CRP均明显高于阴性组患者，差异有统计学意义（P〈0．05）。结论Hp感染与COPD的发病存在相关性，是COPD潜在的致病因素。

A study on helicobacter pylori infections in patients with chronic obstructive pulmonary disease

Objective To investigate the association between helicobacter pylori and COPD,and the mechanism that Hp lead COPD. Methods Fifty-two patients with acute exacerbations of COPD, 35 patients with stable COPD and 22 healthy subjects were all tested for pulmonary function test, urea 13C breath test,and serum were measured C-reactie protein,WBC. Results There is no significantly difference between the positive rate of Hp in patients with acute exacerbations of COPD and that in stable COPD （ P 〉0.05） ,but the positive rates of Hp in patients with acute exacerbations of COPD and stable COPD, compared with healthy subjects,were significantly different （ P M0.01） acute exacerbations patients of COPD with Hp infection by serum C-reactie protein, white blood cells than the total number of non-Hp infection were significently higher （ P M0.01）. Conclusions Hp infection associated with COPD,and Hp infection may be a potential disease risk factors.