二尖瓣狭窄患者气道高反应性与糖皮质激素吸入的治疗 …

目的 了解气道反应性增高和二尖瓣狭窄患者咳嗽及气短症状间的关系，以及糖皮质激素吸入的治疗作用。方法 测定２３例二尖瓣狭窄患者的气道反应性，对１５例（６５％）气道反应性增高者，随机分为丙酸倍氯米松治疗组（８例）和安慰剂组（７例），治疗６周后复查。治疗前后测定患者咳嗽及气短症状评分。对８名气道反应性正常者亦吸入丙酸倍氯米松作为对照组。结果 丙酸倍氯米松吸入组治疗６周后，其气道反应性显著降低（Ｐ〈０．０

Bronchial hyperreactivity in patients with mitral stenosis and therapeutic effect of inhaled corticosteroids

Objective To assess the role of bronchial hyperreactivity (BHR) in patients with mitral stenosis and to evaluate the effect of inhaled corticosteroids in treating these patients. Methods Histamine bronchial provocation testing was performed in 23 patients with mitral stenosis. Patients with BHR were randomized into beclomethasone treatment and placebo group. Patients without BHR were also treated with beclomethasone as controls.Results 15 patients showed BHR. His PD 20 FEV 1 were significantly higher after 6 weeks treatment ( P <0.05), and symptom scores significantly lower( P <0.05)in beclomethasone treatment group while remained unchanged in placebo group( P >0.05).Conclusions BHR is commonly found in patients with symptomatic mitral stenosis. Beclomethasone can significantly decrease bronchial reactivity to histamine and improve symptoms in patients with mitral stenosis.