全血微量元素含量与妊娠期高血压相关性研究

目的探讨妊娠高血压的发生发展与全血微量元素含量的关系，为妊娠期高血压的预防及治疗提供理论依据。方法按妊娠期高血压疾病诊断标准将入选的78例晚孕孕妇分为妊娠期高血压、子痫前期轻度、子痫前期重度3个组，40例正常健康晚孕孕妇为对照组；采用火焰原子吸收光谱法分别测定患病组和对照组孕妇全血微量元素（铜、锌、钙、镁、铁）浓度水平，对数据统计处理并进行对照研究。结果患病各组与对照组比较微量元素铜、钙、镁含量无显著性差异（P〉0．05）；微量元素锌含量在正常对照组、妊娠高血压组、子痫前期轻度组、子痫前期重度组之间依次递减，妊娠高血压组与对照组比较无显著性差异（P〉0．05），子痫前期轻、重度组锌元素含量显著低于对照组，差异有统计学意义（P〈0．05），子痫前期轻、重度组锌元素含量显著低于妊娠高血压组，差异有统计学意义（P〈0．05），子痫前期重度组锌元素含量显著低于子痫前期轻度组，差异有统计学意义（P〈0．05）；微量元素铁含量在正常对照组、妊娠高血压组、子痫前期轻度组、子痫前期重度组之间依次递增，妊娠高血压组与对照组比较无显著性差异（P〉0．05），子痫前期轻、重度组铁元素含量显著高于对照组，差异有统计学意义（P〈0．05），子痫前期轻、重度组铁元素含量显著高于妊娠高血压组，差异有统计学意义（P〈0．05），子痫前期重度组铁元素含量显著高于子痫前期轻度组，差异有统计学意义（P〈0．05）。结论妊娠高血压是孕期常见合并症，要加强妊高征孕妇微量元素的均衡摄入，确保母婴健康。

The study on the relationship between trace elements content in whole blood and hypertensive disorder complicating pregnancy.

Objective： To explore the relationship between the development of pregnancy - induced hypertension and the content of trace elements in whole blood, to provide the theoretical basis for the prevention and treatment of pregnancy - induced hypertension. Methods ： 78 cases of late pregnant women were divided into three groups of pregnancy - induced hypertension group, mild preeelamp- sia group and severe preeclampsia group according to the diagnostic criteria of hypertensive disorder complicating pregnancy, the five trace elements （Copper, Zinc, Calcium, Magnesium, Iron） concentration levels in whole blood with the sick groups and the control group were respectively determinated by flame atomic absorption spectrometry, then statisticed the data and completed comparative studies. Results ： The concentration levels of copper, calcium and Magnesium elements was no significant differences between the sick and the control （ P 〉 0. 05 ） ; the content of trace element zinc was decreasing in accordance with the control group, pregnancy - in- duced hypertension group, mild preeclampsia group, severe preeelampsia group order, the pregnancy - induced hypertension group was no significant differences compared with the control group （ P 〉 0. 05 ） , the mild, severe preeclampsia groups were lower than the control group in zinc concentration levels, the differences was significance （ P 〈 0. 05 ） , the mild, severe preeclampsia groups were lower than the pregnancy - induced hypertension group in zinc concentration levels, the differences was statistically significance （ P 〈 0. 05 ） , the severe preeclampsia group was lower than the mild preeclampsia group in zinc concentration levels, the differences was statistically significance （ P 〈 O. 05 ） ; the content of trace element iron was increasing in accordance with the control group, pregnancy -induced hypertension group, mild preeclampsia group, severe preeclampsia group order, the pregnancy - induced hypertension group was no significant differences compared with the control group （ P 〉 0.05 ） , the mild, severe preeclampsia groups were higher than the control group in iron concentration levels, the differences was statistically significance （ P 〈 0. 05 ） , the mild, severe pre- eclampsia groups were higher than the pregnancy - induced hypertension group in iron concentration levels, the differences was statisti- cally significance （ P 〈 0. 05 ） , the severe preeclampsia group was higher than the mild preeclampsia group in iron concentration lev- els, the differences was statistically significance （ P 〈 0. 05 ）. Conclusion ： Pregnancy - induced hypertension was common complica- tions during pregnancy, we should strengthen the balance of trace elements intake during pregnant women with pregnancy - induced hypertension, so as to ensure maternal and fetal health.