140例三阴乳腺癌病例分析

目的：回顾性分析140例三阴乳腺癌病例，旨在了解该院三阴乳腺癌生存及复发情况。方法：收集中山大学肿瘤防治中心2000—2002年间收治的1125例乳腺癌手术病例，其中140例三阴乳腺癌（其诊断主要基于免疫组化）的病例资料，回顾性分析患者生存情况以及肿瘤复发转移方式。结果：140例三阴乳腺癌患者中位随访时间58个月，5年无病生存率为65．7％，5年总生存率为73．4％。同时期（2000～2002年）该院手术后总的乳腺癌共1125例，5年生存率为86．7％。二者生存率比较（73．4％VS86．7％）有统计学意义。78例绝经前三阴乳腺癌患者5年生存率为75．0％，62例绝经后患者5年生存率为71．3％。有45例三阴乳腺癌发生复发转移，其中17例（37．8％）肝转移，23例（51．1％）肺转移，7例（15．6％）脑转移。结论：与总的乳腺癌比较，三阴乳腺癌的预后更差；绝经前后三阴乳腺癌生存率比较无统计学意义；淋巴结阳性三阴乳腺癌生存差于淋巴结阴性的三阴乳腺癌；与总的乳腺癌比较，三阴乳腺癌复发转移以内脏（肺，肝）转移和脑转移多见。

Retrospective analysis of 140 triple-negative breast cancers

Objective:Retrospectively analyzed 140 triple-negative cases from Cancer Center of Sun Yat-sen University between 2000 and 2002 years to get the message about survival and recurrence of triple negative hreast cancers.Methods:Collected 1 125 postoperative breast cancers from Cancer Center of Sun Yat-sen University between 2000 and 2002 years (including 140 triple-negative patients,diagnosis mainly based on immunohistochemistry) and analyzed recurrence,metastases and survival of them.Results:As of November 2007,with a median follow-up time of 56.4±22.8 months,78 patients are premenopausal.At 5 years,the triple negative had a disease-free survival rate 65.7% and had a survival rate 73.4%.There were 1 125 postoperative breast cancers which had survival rate 86.7% at 5 years in Cancer Center of Sun Yat-sen University between 2000 and 2002 years.Of 140 triple negative breast cancers,78 premenopausal with the 5-year survival rate 75.0%,62 post-menopausal with the 5-year survival rate 71.3%.Among 45 recurrent and metastatic (of 140 triple negative breast cancers),Found 17(37.8%) liver metastatic,23(51.1%)lung metastatic,7 (15.6%) brain metastatic.Conclusion:Triple negative with poorer survival at five years compared with the whole breast cancers over the same time interval (73.4% v 86.7%,respectively).Whether triple negative breast cancers were premenopausal or post-menopausal,the difference of 5-year survival rate was not statistically significant (75.0% v 71.3%,respectively).The triple negative breast cancers with positive lymph node had poorer survival than the triple negative breast cancers with negative lymph node;Internal organ metastases and brain metastases occurred more easily for triple negative breast cancers.