肺癌的副肿瘤性神经综合征20例分析

目的 探讨肺癌的副肿瘤性神经综合征（PNS）的临床特点以防止肺癌诊断的延误。方法 对我院1991-01-2002-01住院的20例经病理和细胞学确诊肺癌并PNS患的临床资料进行回顾性分析。结果 肺癌并PNS发生率为2.2%(20/919)，其中LambertEaton肌无力综合征8例，感觉运动性神经病5例，脑脊髓炎3例，感觉性神经病1例，癌的关系不熟悉或重视不够是延误诊断的主要原因。对有PNS应进一步检查以减少肺癌的误（漏）诊率。

Clinical Analysis of 20 Cases of Paraneoplastic Neurological Syndromes Resulted from Lung Cancer

Objective To discuss the clinical features of paraneoplastic neurological syndromes(PNS) of lung cancer in order to prevent misdiagnosis of lung caner.Methods The clinical data of 20 patients with PNS of lung cancer confirmed by pathology or cytology were analyzed retrospectively.Results The incidence rate of PNS resulted from lung cancer was 2.2%(20/919) in this group.There were 8 cases of Lambert Eaton's myasthenia syndrome,5 sensorimotor neuropathy,3 encephalomyelitis,1 sensory neuropathy,1 subacute cerebellar degeneration,1 necrotic myelopathy,and 1 opsoclonus.The misdiagnosis rate at first consultation was 85%.Conclusion The main reason for misdiagnosis was that clinical physicians were not familiar with the relationship between PNS and lung carcer.For patients with PNS,further examinations should be done to aviod misdiagnosis of lung cancer.