151例腮腺恶性肿瘤临床病理特征分析

  目的  探讨腮腺恶性肿瘤的临床特点及影响预后的因素。  方法  收集2011年1月至2018年10月于天津医科大学肿瘤医院治疗并经病理证实为腮腺恶性肿瘤的151例患者的临床资料，并对其临床病理特征及生存情况进行回顾性分析。  结果  151例腮腺恶性肿瘤患者中，病理类型包括黏液表皮样癌、腺泡细胞癌、涎腺导管癌、腺样囊性癌、非特异性腺癌。病理类型（P=0.001）、年龄（P=0.049）、面神经麻痹（P<0.001）、镜下神经侵犯（P<0.001）、TNM分期（P<0.001）、临床分期（P<0.001）、肿瘤复发（P<0.001）、术后辅助放疗（P<0.001）与腮腺恶性肿瘤患者的预后相关。其中肿瘤复发（P=0.001）和临床分期（P=0.004）为影响腮腺恶性肿瘤预后的主要因素。  结论  肿瘤复发和临床分期是影响腮腺恶性肿瘤患者预后的独立危险因素，为判断腮腺恶性肿瘤预后和制定个体化治疗方案提供了重要依据。 

Clinical and pathological analysis of patients with parotid gland carcinoma

  Objective  To explore the clinical characteristics and prognostic factors of parotid gland carcinoma.   Methods  The clinical data of 151 patients with pathologically confirmed parotid gland carcinoma at Tianjin Medical University Cancer Institute & Hospital from January 2011 to October 2018 were collected. The patients’ clinicopathological features and survival outcomes were analyzed retrospectively.   Results  The pathological types identified in 151 patients with parotid gland carcinoma included: mucoepidermoid carcinoma, acinic cell carcinoma, salivary duct carcinoma, adenoid cystic carcinoma, and adenocarcinoma. The pathological type (P=0.001), age (P=0.049), facial paralysis (P<0.001), microscopic nerve invasion (P<0.001), TNM stage (P<0.001), clinical stage (P<0.001), tumor recurrence (P<0.001), and postoperative adjuvant radiotherapy (P<0.001) were associated with prognosis in patients with parotid gland carcinoma. Moreover, tumor recurrence (P=0.001) and clinical stage (P=0.004) were the main prognostic factors of parotid gland carcinoma.   Conclusions  Tumor recurrence and clinical stage were found to be independent prognostic risk factors in patients with parotid gland carcinoma. This provides important basis for estimating the disease prognosis and formulating individualized treatment plans.