| 内质网–线粒体交互在心血管疾病中的作用研究进展 |
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| 引用本文： | 张滋彬,贾敏,王敏,张鹏飞,张海锋,高峰,邢文娟. 内质网–线粒体交互在心血管疾病中的作用研究进展[J]. 心脏杂志, 2020, 32(5): 522-527. DOI: 10.12125/j.chj.202006027 |
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| 作者姓名： | 张滋彬 贾敏 王敏 张鹏飞 张海锋 高峰 邢文娟 |
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| 作者单位： | 1.基础医学院一大队一队 空军军医大学 |
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| 基金项目： | 国家自然科学基金项目资助（81700342，81870280）；陕西省高校科协青年人才托举计划项目资助（20180302）；陕西省自然科学基础研究计划项目资助（2019JQ-330）；航空航天一流学科建设人才引导专项人才创新基金项目资助（2019HBRC06） |
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| 摘 要： | 线粒体和内质网的稳态在维持心血管正常功能中发挥重要作用，线粒体或内质网的结构功能异常参与了众多心血管疾病的发生发展。近年来研究发现线粒体与内质网存在物理和功能的交互，其交互作用调控线粒体、内质网功能，进而影响心肌细胞和平滑肌细胞的线粒体动力学平衡、钙转运及磷脂合成和转运。内质网–线粒体交互异常被认为是冠心病、心力衰竭、肺动脉高压和动脉粥样硬化等心血管疾病的关键机制。因此，理解内质网-线粒体交互机制可为预防和改善心血管疾病提供崭新靶点。
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| 关 键 词： | 心血管疾病 内质网–线粒体交互 线粒体动力学 钙离子 线粒体相关内质网膜 |
| 收稿时间： | 2020-06-08 |
Research advance in effects of endoplasmic reticulum-mitochondria interaction on cardiovascular diseases |
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| Affiliation: | 1.First Battalion, First Cadet Regiment2.Department of Physiology4.Teaching Experiment Center, School of Basic Medical Sciences3.Department of Aerospace Kurortology and Rehabilitation, School of Aerospace Medicine, Air Force Medical University, Xi’an 710032, Shaanxi, China |
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| Abstract: | Homeostasis of mitochondrion and endoplasmic reticulum (ER) maintains normal cardiovascular functions. Structural and functional disorders in mitochondrion or ER are involved in the development of many cardiovascular diseases. In recent years, ER-mitochondria contact points were recognized and the interaction was reported to control mitochondrial dynamics, calcium transfer and lipid exchange in both cardiomyocytes and vascular smooth muscle cells. Moreover, abnormal ER-mitochondria interaction was reported as one of the key mechanisms of coronary artery disease, heart failure, pulmonary arterial hypertension and atherosclerosis. Therefore, the ER-mitochondria interaction might be a new promising target for cardiovascular diseases. |
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