肿瘤电场治疗原理及疗效影响因素研究进展

随着交流电场在医学领域的研究和应用逐步深入,研究人员发现低强度和中频交变电场对肿瘤具有良好的治疗作用,此类治疗方法被称为肿瘤电场治疗(tumor-treating fields,TTFields)。研究表明TTFields的直接作用机制包括干扰微管和隔膜蛋白的形成与定位,形成介电电泳导致细胞结构破坏,间接作用包括抑制肿瘤细胞的迁移、侵袭和肿瘤血管的生成,影响肿瘤免疫微环境、细胞膜的通透性和抑制DNA修复等。同时影响TTFields效果的相关因素有很多,如电场频率、强度、作用时间和交变电场的方向以及治疗对象的解剖结构等。本文就TTFields的作用原理及影响疗效的相关因素进行综述,以期为临床诊治提供参考。

Advances in mechanism of tumor-treating fields and related factors for its efficacy

With further advances in the research and application of alternating current electric fields in the medical field, researchers have found that low-intensity and medium-frequency alternating current electric fields have good therapeutic effects on tumors, which are called tumor electric field therapy or tumor-treating fields (TTFields).Studies have shown that the direct mechanism of TTFields includes interfering with the formation and localization of microtubules and diaphragm proteins, formation of dielectrophoresis, and destruction of cell structure.Indirect effects include the inhibition of tumor cell migration, invasion, and tumor angiogenesis, thereby affecting the tumor immune microenvironment and cell membrane permeability and inhibiting DNA repair.Concurrently, many factors, such as electric field frequency, intensity, action time, direction of alternating electric field, and anatomical structure with the treatment object, influence the effect of TTFields.In this review, the mechanism of TTFields and related factors affecting the curative effect were assessed to provide reference for clinical diagnosis and treatment.