2011-2019年我国G9P[8]型A组轮状病毒腹泻住院患儿流行病学和临床特征分析

目的 了解我国G9P[8]型A组轮状病毒(Group A Rotavirus, RVA)腹泻住院患儿的流行病学和临床特征。方法 收集2011年1月至2019年12月我国病毒性腹泻监测网络数据。监测网数据采用EpiData 3.0软件采集,采用Excel 2010软件数据整理,应用SPSS 26.0软件数据分析。结果 2011年1月至2019年12月采集到我国病毒性腹泻监测网络5岁以下急性胃肠炎住院患儿标本共计47 386份,其中G9P[8]型RVA阳性率为54.50%(8 149/14 952),G9P[8]型RVA在男性患儿中占比低于女性患儿。G9P[8]型RVA的流行季节为秋冬季。G9P[8]型RVA相对于非G9P[8]型RVA患儿在发热(59.79%,4 872/8 149)、呕吐(53.87%,4 390/8 149)、腹泻(92.93%,7 573/8 149)、肠道外症状的呼吸道症状(29.30%,2 388/8 149)、神经系统症状(2.07%,169/8 149)、mber>/8 149、神经系统症状(2.07%,169/8 149)、皮疹、肺炎、败血症(8.21%,669/8 149)等症状/体征多发且严重。结论 2011年1月至2019年12月我国G9P[8]型RVA逐渐成为我国的流行优势毒株,季节高峰为秋冬季,G9P[8]型RVA症状更重。本研究为RVA防控提供基础数据支持,为RVA疫苗候选毒株选择提供参考。

Epidemiological and clinical characteristics of hospitalized children with G9P[8] group A rotavirus diarrhea in China from 2011 to 2019

  Objective  To understand the epidemiological and clinical characteristics of G9P[8] group A rotavirus (RVA) in hospitalized children with diarrhea in China.  Methods  The data of viral diarrhea surveillance network in China from January 2011 to December 2019 were collected, EpiData 3.0 software were used for data collection of viral diarrhea monitoring network, Excel 2010 software were used for data collation, and SPSS 26.0 software was used for data analysis.   Results  From January 2011 to December 2019, a total of 47 386 specimens of hospitalized children with acute gastroenteritis under 5 years old were collected by the viral diarrhea surveillance network in China. The positive rate of G9P[8] RVA was 54.50％ (8 149/14 952).The positive rate of G9P[8] RVA in male children was lower than in female children. The epidemic season is autumn and winter. Compared with non-G9P[8] RVA children, G9P[8] RVA children had more severe and higher proportion of fever (59.79％, 4 872/8 149), vomiting (53.87％, 4 390/8 149), diarrhea (92.93％, 7 573/8 149), respiratory symptoms (29.30％, 2 388/8 149), neurological symptoms (2.07％, 169/8 149), rash, pneumonia and sepsis (8.21％, 669/8 149) .  Conclusion  From January 2011 to December 2019, G9P[8] RVA gradually became the main predominant in China. The autumn and winter were G9P[8] RVA seasonal peaks, and the symptoms of G9P[8] RVA were more severe. This study provides data support for the prevention and control of G9P[8] RVA, and reference for the selection of rotavirus vaccine strain.