血清CD26对于甲状腺乳头状癌的诊断价值及临床意义

目的:探讨血液中可溶性CD26(soluble CD26,s CD26)对于甲状腺乳头状癌(papillary thyroid carcinoma,PTC)诊断的价值及其临床意义。方法:收集2013年1月至2017年12月天津医科大学总医院行手术治疗的104例PTC患者临床病例资料,同期行手术治疗的甲状腺良性肿瘤患者25例及健康人群55例作为对照组。分别收集各组空腹血液样本,应用ELISA法测定s CD26浓度,记录PTC患者的临床病理特征,分析s CD26浓度对PTC的诊断价值及其与临床病理特征的关系。结果:PTC患者术前s CD26浓度升高,与良性病变组和健康对照组比较呈显著性差异(P<0.05);术后s CD26浓度下降,与术前比较呈显著性差异(P<0.05),与良性病变组和健康对照组无显著性差异(P>0.05)。以s CD26区分PTC与甲状腺良性病变的敏感性、特异性、诊断准确率分别为75.50%、91.21%、85.00%,最佳诊断界值为545.20 ng/m L。经χ²检验,s CD26高浓度与PTC患者肿瘤大小≥4.0 cm和临床分...

Diagnostic value and clinical significance of serum CD26 in papillary thyroid carcinoma

  Objective   To investigate the value and clinical significance of soluble CD26 (sCD26) in blood in the diagnosis of papillary thyroid carcinoma (PTC).  Method  A total of 104 PTC patients who had undergone surgery at the Tianjin Medical University General Hospital from January 2013 to December 2017 were collected as the study group. In the study period, surgery had been performed for 25 cases of a benign thyroid lesion, who served as control group. The control also group included 55 cases that had undergone health examination. The fasting blood samples of the PTC group before and after the operation and those of the control group were collected. The sCD26 concentration was determined by ELISA. Clinical pathology features of PTC patients were recorded to analyze the diagnostic value of the sCD26 concentration on PTC and its relationship with clinicopathological features.   Results  The preoperative sCD26 concentration in PTC patients increased and significantly differed from the control groups. The sCD26 concentration had significantly decreased postoperatively compared to the preoperative value but showed no significant difference from the control group. The sensitivity, specificity, diagnostic accuracy, and optimal diagnostic boundary values for sCD26 distinguishing thyroid carcinoma from benign thyroid lesions were 75.50%, 91.21%, 85.0%, and 545.20 ng/mL, respectively. The results of the chi-square test showed a significant correlation of the high concentration of sCD26 with the tumor size ≥4.0 cm and clinical stage Ⅲ in patients with PTC, but there was no significant correlation with the sex, age, lymph node metastasis, tumor capsule invasion, or preoperative TI-RADS classification.   Conclusions  The sCD26 concentration has a diagnostic value for PTC and may be an independent predictor of the PTC prognosis.