PD-1 PD-L1单抗在复发转移性鼻咽癌中的研究进展 |
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引用本文: | 张溪夏,曹志伟.PD-1 PD-L1单抗在复发转移性鼻咽癌中的研究进展[J].中国肿瘤临床,2020,47(23):1231-1235. |
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作者姓名: | 张溪夏 曹志伟 |
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作者单位: | 中国医科大学附属盛京医院耳鼻咽喉科(沈阳市 110001) |
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摘 要: | 鼻咽癌患者经放疗及同步辅助化疗后,临床转归有所改善,但肿瘤复发及远处转移仍为一项难题。近些年,免疫检查点抑制剂的发现为肿瘤的免疫治疗提供了新的选择。其中,程序性细胞死亡受体1(programmed cell death protein-1,PD-1)/程序性死亡受体配体1(programmed cell death 1-ligand,PD-L1)单抗受到广泛关注且已应用于临床治疗。本文就帕博利珠单抗、纳武利尤单抗、卡瑞利珠单抗和特瑞普利单抗等PD-1/PD-L1单抗在复发/转移性鼻咽癌中的研究进展进行综述。
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关 键 词: | PD-1 PD-L1 鼻咽癌 |
收稿时间: | 2020-08-24 |
Research progress of PD-1/PD-L1 monoclonal antibodies in recurrent/metastatic nasopharyngeal carcinoma |
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Institution: | Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110001, China |
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Abstract: | Clinical outcomes of patients with nasopharyngeal carcinoma have improved after radiotherapy and concurrent adjuvant chemotherapy. However, tumor recurrence and distant metastasis remain a problem. In recent years, immune checkpoint inhibitors have provided new options for tumor immunotherapy. Among immune checkpoint inhibitors, programmed cell death protein-1 (PD-1)/ programmed cell death protein-ligand 1 (PD- L1) monoclonal antibodies have received widespread attention and have been used in clinical treatments. This article reviews the research progress of pembrolizumab, nivolizumab, carrelizumab, teriprizumab, and other PD-1/PD-L1 monoclonal antibodies in recurrent/metastatic nasopharyngeal carcinoma. |
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