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新辅助化疗对乳腺癌ER PR HER-2及Ki-67表达影响的研究进展
引用本文:何洋,赵伟鹏,佟仲生.新辅助化疗对乳腺癌ER PR HER-2及Ki-67表达影响的研究进展[J].中国肿瘤临床,2020,47(22):1185-1188.
作者姓名:何洋  赵伟鹏  佟仲生
作者单位:天津医科大学肿瘤医院乳腺肿瘤内科, 国家肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心, 乳腺癌防治教育部重点实验室(天津市 300060)
摘    要:目前乳腺癌已成为女性发病率最高的恶性肿瘤,新辅助化疗(neoadjuvant chemotherapy,NAC)后雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)、Ki-67表达情况会有不同程度变化,这种变化机制是否会影响后续治疗方案的选择尚无定论。本文将就NAC对乳腺癌ER、PR、HER-2及Ki-67表达影响的研究进展进行综述。 

关 键 词:乳腺癌    新辅助化疗    雌激素    孕激素    人表皮生长因子受体-2    Ki-67
收稿时间:2020-06-30

Research progress on impact of neoadjuvant chemotherapy on the expression of ER,PR, HER-2, and Ki-67 in breast cancer
Institution:Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University(Ministry of Education), Tianjin 300060, China
Abstract:Breast cancer has the highest incidence rate among all malignancies in women. The expression of estrogen receptors (ERs), progesterone receptors (PRs), human epidermal growth factor receptor-2 (HER-2), and Ki-67 changes to varying degrees after neoadjuvant chemotherapy. Whether the mechanism underlying these changes will affect the choice of subsequent treatment options remains unknown. We summarize the research progress of neoadjuvant chemotherapy on the expression of ER, PR, HER-2 and Ki-67 in breast cancer. 
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