| RNA m5C甲基化修饰在肿瘤中的研究进展 |
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| 引用本文： | 张安琪,安萌,姜博,唐文强,潘丽,付波. RNA m5C甲基化修饰在肿瘤中的研究进展[J]. 中国肿瘤临床, 2021, 48(24): 1277-1281. DOI: 10.12354/j.issn.1000-8179.2021.20210966 |
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| 作者姓名： | 张安琪 安萌 姜博 唐文强 潘丽 付波 |
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| 作者单位： | 1.山东第一医科大学附属聊城医院,聊城市人民医院中心实验室 （山东省聊城市252000） |
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| 基金项目： | 本文课题受国家自然科学基金项目（编号:81702884）资助 |
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| 摘 要： | 5-甲基胞嘧啶(5-methylcytosine,m5C)是RNA中重要的甲基化修饰之一,也是近年来的研究热点.随着甲基化测序技术的发展,在编码RNA及非编码RNA中均证实存在大量的m5C甲基化修饰.RNA m5C甲基化修饰受m5C甲基转移酶、去甲基化酶及m5C甲基化结合蛋白的调控.m5C甲基化修饰调节RNA的稳定性、...
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| 关 键 词： | m5C甲基化修饰 编码RNA 非编码RNA 肿瘤 |
| 收稿时间： | 2021-06-22 |
Research progress on post-translational RNA 5-methylcytosine methylation in tumors |
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| Affiliation: | 1.Department of Central Laboratory,2.Department of Clinical Laboratory, Liaocheng People’s Hospital, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng 252000, China |
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| Abstract: | 5-methylcytosine (m5C) is an important post-translationally modified base in RNA formed by cytosine methylation. As the development of methylation sequencing techniques, extensive m5C modifications have been found in both coding and non-coding RNA. Incorporation of m5C into RNA is regulated by methyltransferases, demethylases, and m5C-binding proteins. m5C incorporation regulates RNA stability, transport, translation, and pressure stress. Recent studies have revealed that m5C incorporation into RNA is involved in the regulation of tumor pathogenesis, development, invasion, metastasis, and resistance. This article reviews m5C-mediated regulatory mechanisms and functions, and research progress on m5C-modified RNA functions in tumors, thus providing novel insights for developing innovative tumor diagnostic and therapeutic strategies. |
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