| 淋巴瘤表观遗传学靶向治疗的进展 |
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| 引用本文： | 苗昭艺,赵智刚. 淋巴瘤表观遗传学靶向治疗的进展[J]. 中国肿瘤临床, 2020, 47(7): 359-364. DOI: 10.3969/j.issn.1000-8179.2020.07.330 |
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| 作者姓名： | 苗昭艺 赵智刚 |
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| 作者单位： | 天津医科大学肿瘤医院血液科, 国家肿瘤临床医学研究中心, 天津市肿瘤防治重点实验室, 天津市恶性肿瘤临床医学研究中心(天津市 300060) |
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| 基金项目： | 国家自然科学基金项目81670102国家自然科学基金项目81870150天津市自然科学基金项目16JCYBJC25200 |
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| 摘 要： | 淋巴瘤是一类起源于淋巴结和淋巴组织的异质性肿瘤。表观遗传学为研究不改变DNA序列,基因表达改变可遗传的一门新兴学科。淋巴瘤的发病、进展与表观遗传异常密切相关。针对表观遗传异常的靶向药物,主要包括DNA甲基转移酶抑制剂(DNA methyltransferase inhibitors,DNMTis)、组蛋白去乙酰化酶抑制剂、EZH2抑制剂、PRMT抑制剂及BET抑制剂等,在淋巴瘤的靶向治疗中凸显出绝对优势。本文分析近年来表观遗传药物在淋巴瘤中的治疗进展,旨在为淋巴瘤的靶向治疗提供新思路。
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| 关 键 词： | 表观遗传学 靶向治疗 淋巴瘤 |
| 收稿时间： | 2020-03-20 |
Advances in epigenetic modulation-based therapies for lymphoma |
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| Zhaoyi Miao,Zhigang Zhao. Advances in epigenetic modulation-based therapies for lymphoma[J]. Chinese Journal of Clinical Oncology, 2020, 47(7): 359-364. DOI: 10.3969/j.issn.1000-8179.2020.07.330 |
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| Authors: | Zhaoyi Miao Zhigang Zhao |
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| Affiliation: | Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China |
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| Abstract: | Lymphomas are a group of heterogeneous tumors originating from lymphocytes at various stages of differentiation. Epigenetics is an emerging discipline of science that studies heritable changes in the DNA sequences and gene expression patterns of organisms. Studies have shown that the development and progression of lymphomas are closely related to epigenetic abnormalities. Drugs targeting epigenetic abnormalities, including DNA methyltransferase inhibitors, histone deacetylase inhibitors, EZH2 inhibitors, PRMT inhibitors, and BET inhibitors, have been studied extensively and have shown many advantages in the treatment of lymphomas. This article reviews the recent advances in epigenetic drugs for treatment of lymphomas to provide new ideas for treatment strategies for lymphoma. |
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| Keywords: | epigenetics targeted therapy lymphoma |
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