Urinary C-peptide in the neonate correlates both to maternal glucose tolerance and to fetal size at birth |
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Authors: | N O Lunell B Persson L V Devarajan S Hassan H Hathout R Kasrawi A Saleh L Viktorin |
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Institution: | Department of Obstetrics and Gynecology, Huddinge University Hospital, Sweden. |
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Abstract: | In 18 women with gestational diabetes the variables of an oral glucose tolerance test (fasting and 2-hour blood glucose values and area under the blood glucose curve) performed in the last trimester of pregnancy correlated significantly with the urinary C-peptide excretion during the first 12 hours of the life (r = 0.47, 0.71, and 0.60, respectively). In a combined group with 28 type II pregnant diabetic women there was also a significant correlation between the urinary C-peptide excretion of the infants and their skinfold. Assay of the urinary C-peptide excretion of the neonate, reflecting its insulin production, seems to be a sensitive parameter to study the influence of the maternal carbohydrate metabolism in the offspring. |
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