| 埃兹蛋白、转移相关黏附分子44V6、E-钙黏附素在人结肠癌组织中的表达及其意义 |
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| 引用本文： | 李海英. 埃兹蛋白、转移相关黏附分子44V6、E-钙黏附素在人结肠癌组织中的表达及其意义[J]. 中国全科医学, 2011, 14(12) |
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| 作者姓名： | 李海英 |
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| 作者单位： | 河北省唐山市工人医院消化内科,063000 |
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| 摘 要： | 目的 探讨埃兹蛋白(Ezrin蛋白)、转移相关黏附分子44V6(CD44V6)、E-钙黏附素在人结肠癌组织中的表达及意义.方法 应用免疫组化S-P法检测Ezrin、CD44V6、E-钙黏附素在78例结肠癌组织、30例结肠腺瘤组织、30例正常结肠黏膜中的表达,分析三者与临床病理特征的关系及相关性.结果 结肠癌组织中Ezrin、CD44V6蛋白表达阳性率显著高于结肠腺瘤组织及正常结肠组织(P＜0.01),而有淋巴转移者显著高于无淋巴转移者(P＜0.05);E-钙黏附素蛋白表达阳性率显著低于结肠腺瘤及正常结肠黏膜组织(P＜0.01),无淋巴转移组明显高于有淋巴转移组(P＜0.01).结肠癌组织中Ezrin、CD44V6蛋白表达水平与肿瘤进展及转移呈正相关(P＜0.05),而E-钙黏附素蛋白表达水平与肿瘤进展及转移呈负相关(P＜0.05).结论 Ezrin、CD44V6、E-钙黏附素可能与结肠癌的侵袭转移相关,三者联合检验能更准确地判断结肠癌的转移情况.
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| 关 键 词： | 结肠肿瘤 E-钙黏附素 免疫组织化学 |
Expression of Ezrin,CD44V6 and E-cadherin in Tissues of Colon Carcinoma and Its Significance |
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| LI Hai-ying. Expression of Ezrin,CD44V6 and E-cadherin in Tissues of Colon Carcinoma and Its Significance[J]. Chinese General Practice, 2011, 14(12) |
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| Authors: | LI Hai-ying |
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| Affiliation: | LI Hai-ying.Department of Gastroenterology,Gongren Hospital,Tangshan 063000,China |
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| Abstract: | Objective To investigate the expression of Ezrin,CD44V6 and E-cadherin in tissues of colon carcinoma and its significance.Methods Immunohistochemistry(IHC) method(SP method)was used to examine the expression of Ezrin,CD44V6 and E-cadherin in 78 cases colon carcinoma,30 cases colorectal adenomas and 30 cases normal colonic mucosa.Their relationships with clinicopathological features were analyzed.Results The positive expression rate of Ezrin and CD44V6 in colon cancer tissues was significantly higher than th... |
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| Keywords: | Ezrin CD44V6 |
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