| 血管紧张素原基因启动子区A-20C和A-6G单核苷酸多态性与原发性高血压的相关性研究 |
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| 引用本文： | 龚洪涛,郭一力,杜凤和.血管紧张素原基因启动子区A-20C和A-6G单核苷酸多态性与原发性高血压的相关性研究[J].中国全科医学,2011,14(17). |
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| 作者姓名： | 龚洪涛 郭一力 杜凤和 |
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| 作者单位： | 首都医科大学附属北京天坛医院心内科,北京市,100050 |
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| 摘 要： | 目的 探讨血管紧张素原(AGT)基因启动子区A-20C和A-6G单核苷酸多态性与原发性高血压病(EH)之间的关系.方法 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对200例汉族高血压患者和192例汉族正常血压者的AGT基因-20A/C和-6A/G多态性进行检测,测定空腹血糖、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)等生物化学指标,分析各基因型和等位基因频率与原发性高血压的关系.结果 -20A/C各基因型及等位基因频率在高血压组及对照组间差别无统计学意义(χ2=2.226,P =0.136;χ2=1.78,P =0.182);-6A/G各基因型及等位基因频率在高血压组及对照组间差别亦无统计学意义(χ2=0.012,P =0.911;χ2=0.052,P =0.82).结论 AGT基因-20A/C和-6A/G多态性与原发性高血压发病无关.
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| 关 键 词： | 血管紧张素原 原发性高血压 基因多态性 |
Relationships between Mononucleotide Polymorphism of Angiotensinogen Gene at Promoter A-20C and A-6G and Primary Hypertension |
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| GONG Hong-tao,GUO Yi-li,DU Feng-he.Relationships between Mononucleotide Polymorphism of Angiotensinogen Gene at Promoter A-20C and A-6G and Primary Hypertension[J].Chinese General Practice,2011,14(17). |
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| Authors: | GONG Hong-tao GUO Yi-li DU Feng-he |
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| Institution: | GONG Hong-tao,GUO Yi-li,DU Feng-he.Department of Cardiology,Beijing Tiantan Hospital,Capital University of Medical Science,Beijing 100050,China |
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| Abstract: | Objective To investigate the relationship between primary hypertension and mononucleotide polymorphism of A-20C and A-6G at the promoter region of angiotensinogen gene.Methods The study covered 200 hypertension patients and 192 normotensive controls.A-20C and A-6G polymorphism of the AGT gene was determined using polymerase chain reaction-Restriction fragment length polymorphism(PCR-PFLP).Biochemical indices such as serum glucose(GLU) and total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL) ... |
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| Keywords: | Angiotensinogen Essential hypertension Gene polymorphism |
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