| 端粒酶hTERT与p27蛋白在子宫内膜癌中的表达 |
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| 引用本文： | 刘宏侠,李万斌.端粒酶hTERT与p27蛋白在子宫内膜癌中的表达[J].中国热带医学,2011,11(1):99-101. |
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| 作者姓名： | 刘宏侠 李万斌 |
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| 作者单位： | 济宁医学院附属医院,山东,济宁,272000 |
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| 摘 要： | 目的探讨端粒酶hTERT和p27蛋白在子宫内膜癌发生、发展中的作用。方法应用链霉菌素蛋白一过氧化物酶免疫组织化学方法（S～P）对子宫内膜癌组织中端粒酶hTERT、p27蛋白表达进行检测，并与正常增生期子宫内膜组织中两者表达进行对比。结果端粒酶hTERT基因蛋白在子宫内膜癌组织的阳性表达率显著高于正常增生期子宫内膜组（P〈0．05），其表达与年龄、组织学分级、临床分期、肌层浸润、及有无淋巴转移无关。正常增生期子宫内膜组p27蛋白的阳性表达率显著高于子宫内膜癌组（P〈O．05）。p27蛋白在子宫内膜癌中的表达与组织学分级、临床分期、肌层浸润有关，而与年龄和有无淋巴转移无关。在子宫内膜癌中，端粒酶hTERT基因蛋白与p27蛋白的表达存在负相关关系。结论hTERT高表达与p27蛋白的低表达协同作用促进内膜癌的发展，联合检测hTERT与p27蛋白有助于估计预后、指导治疗。
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| 关 键 词： | 子宫内膜癌 细胞周期 端粒酶 p27蛋白 |
Expression and signicance of telomerase Htert and p27 proteins in endometrial carcinoma and normal endometrium tissues |
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| LIU Hong-xia,LI Wan-bin.Expression and signicance of telomerase Htert and p27 proteins in endometrial carcinoma and normal endometrium tissues[J].China Tropical Medicine,2011,11(1):99-101. |
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| Authors: | LIU Hong-xia LI Wan-bin |
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| Institution: | LIU Hong-xia,LI Wan-bin(Affiliated Hospital of Jining Medical College,Jining 272000,Shandong,P.R.China) |
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| Abstract: | Aim To investigate the expressions of telomerase hTERT and p27 proteins in endometrial carcinoma and normal endometrium tissues in proliferative phase.Methods The expression of telomerase hTERT and p27 in endometrial adenocarcinoma and proliferative normal endometrium were detected immunohistochemically.Results The positive expression rate of hTERT in endometrial carcinoma was significantly higher than that of endometrium in proliferative phase(P<0.05).The expression of hTERT in endometrial carcinoma was co... |
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| Keywords: | Endometrial carcinomas Cell cycle Telomerase p27 protein |
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