| 新辅助化疗对乳腺癌雌激素受体和P53基因及人表皮生长因子受体-2的影响及意义 |
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| 引用本文： | 杨海松,黄建军,毛大华,罗轲. 新辅助化疗对乳腺癌雌激素受体和P53基因及人表皮生长因子受体-2的影响及意义[J]. 中国全科医学, 2011, 14(12) |
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| 作者姓名： | 杨海松 黄建军 毛大华 罗轲 |
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| 作者单位： | 贵阳医学院附属医院乳腺外科,贵州省贵阳市,550004 |
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| 摘 要： | 目的 探讨雌激素受体(ER)和P53基因、人表皮生长因子受体-2(HER-2)在新辅助化疗乳腺癌组织的表达及临床意义.方法 采用免疫组织化学方法检测100例乳腺癌患者新辅助化疗前后肿瘤组织中ER、P53基因及HER-2的表达,分析其与疗效的关系.结果 新辅助化疗总有效率为79%,新辅助化疗前ER、P53基因阳性表达和阴性表达患者化疗后有效率比较,差异均有统计学意义(P＜0.05).而新辅助化疗前HER-2阳性表达和阴性表达患者化疗后有效率比较,差异无统计学意义(P＞0.05).新辅助化疗前后ER、P53基因和HER-2表达率比较,差异均无统计学意义(P＞0.05).结论 新辅助化疗对ER、P53 基因及HER-2表达状态无显著影响;ER和P53 基因对乳腺癌新辅助化疗疗效有一定预测价值.
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| 关 键 词： | 乳腺肿瘤 新辅助化疗 抗肿瘤联合化疗方案 基因,P53 |
Effects of Neoadjuvant Chemotherapy on ER,P53 and HER-2 Expression in Breast Cancer |
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| YANG Hai-song,HUANG Jian-jun,MAO Da-hua,et al.. Effects of Neoadjuvant Chemotherapy on ER,P53 and HER-2 Expression in Breast Cancer[J]. Chinese General Practice, 2011, 14(12) |
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| Authors: | YANG Hai-song HUANG Jian-jun MAO Da-hua et al. |
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| Affiliation: | YANG Hai-song,HUANG Jian-jun,MAO Da-hua,et al.Department of Mastopathy,Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China |
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| Abstract: | Objective To explore the expressions of estrogen receptor(ER),P53 gene and human epidermal growth factor receptor(HER-2) in breast cancer tissues treated by neoadjuvant chemotherapy and their clinical significance.Methods Expressions of ER,P53 and HER-2 were determined by immunohistochemistry in 100 breast cancer(BC) patients before and after neoadjuvant chemotherapy and their relationship to the effect.Results The overall response rate to neoadjuvant chemotherapy was 79%.There was significant difference in... |
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| Keywords: | Bresat neoplasm Neoadjuvant chemotherapy Antineoplastic combined chemotherapy Genes P53 |
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