| 夜间酸突破与食管下段酸暴露的相互关系 |
| |
| 引用本文： | 樊力红,王红,戴寿军,李瑜元.夜间酸突破与食管下段酸暴露的相互关系[J].中国全科医学,2011,14(15). |
| |
| 作者姓名： | 樊力红 王红 戴寿军 李瑜元 |
| |
| 作者单位： | 1. 广州医学院第一附属医院消化内科,广东省广州市,510120
2. 广州医学院附属市一人民医院消化内科 |
| |
| 摘 要： | 目的 了解夜间酸突破(NAB)的发生与食管下段酸暴露的相互关系.方法 选取61例十二指肠球部溃疡(DU)患者,均接受质子泵抑制剂(PPI)治疗,即奥美拉唑20 mg/次,2次/d.治疗第5天进行24 h食管、胃pH监测,对夜间胃内pH与食管下端pH相互关系采用一元线性回归方程分析.并把患者分为NAB组与非NAB组,比较两组患者夜间食管下段平均pH值及夜间pH＜4时段所占时间百分比.结果 夜间食管下段平均pH值(x)与胃内平均pH值(y)所作回归方程为:y=4.054+0.288x,回归系数检验P＜0.001.夜间食管下段pH＜4时段所占时间百分比(x)与胃内pH＜4时段所占时间百分比(y)所作回归方程为:y=5.780+0.204x,回归系数检验P＜0.001.NAB组患者夜间食管下段平均pH值(5.31±0.89)显著低于非NAB组(5.92±0.99),差异有统计学意义(P＜0.05);而夜间食管下段pH＜4时段所占时间百分比(39.30%)则显著高于非NAB组(26.32%),差异有统计学意义(P＜0.05).结论 食管夜间平均pH值、pH＜4时段所占时间百分比随胃内相应指标同向变化.DU患者在接受PPI治疗时,发生NAB的患者,其食管下段酸暴露增加.
|
| 关 键 词： | 夜间酸突破 食管下段酸暴露 十二指肠溃疡 |
Relationship between Noctural Acid Break-through and Acid Exposure in Lower Esophagus |
| |
| FAN Li-hong,WANG Hong,DAI Shou-jun,et al..Relationship between Noctural Acid Break-through and Acid Exposure in Lower Esophagus[J].Chinese General Practice,2011,14(15). |
| |
| Authors: | FAN Li-hong WANG Hong DAI Shou-jun |
| |
| Institution: | FAN Li-hong,WANG Hong,DAI Shou-jun,et al.Department of Gastroenterology,the First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China |
| |
| Abstract: | Objective To investigate the correlation between nocturnal acid break-through(NAB) and acid exposure in lower esophagus. Methods Totally 61 patients with duodenal ulcer confirmed by gastroscopy received omeprazole(20 mg twice a day) for 5 days.Ambulatory 24-hour intragastric and esophageal pH monitoring was performed on day 5.The relationship between nocturnal intragastric pH and lower esophagus pH was analyzed using equation of monovariate linear regression.Patients were divided into NAB group and non-NAB ... |
| |
| Keywords: | Nocturnal acid break Acid expose in lower esophagus Duodenal ulcer |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
