| 哈萨克族原发性高血压患者外周血单核细胞Toll样受体4的表达及其相关性研究 |
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| 引用本文： | 段军仓,王丽,王忠,杨云,张望强.哈萨克族原发性高血压患者外周血单核细胞Toll样受体4的表达及其相关性研究[J].中国全科医学,2011,14(9). |
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| 作者姓名： | 段军仓 王丽 王忠 杨云 张望强 |
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| 作者单位： | 石河子大学医学院第一附属医院心内二科,新疆维吾尔自治区石河子市,832008 |
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| 摘 要： | 目的 探讨新疆哈萨克族原发性高血压患者外周血单核细胞Toll样受体4(TLR4)表达及与血脂、血糖、肥胖的相关性.方法 根据高血压诊断标准,选取68例新疆哈萨克族原发性高血压患者为高血压组,70例哈萨克族健康人为对照组,测量血压(BP)、身高、体质量、腰围(WC)、臀围(HC),抽取空腹静脉血测定血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平及白细胞计数(WBC)和单核细胞计数(MC).采用流式细胞仪检查外周血单核细胞上TLR4表达.计算体质指数(BMI)、腰臀比(WHR).结果 高血压组血浆TLR4阳性率高于对照组,差异有统计学意义(P＜0.05);两组BMI、WC、SBP、DBP、TC、LDL-C、WBC、MC比较,差异均有统计学意义(P＜0.05);两组WHR、FPG、TG、HDL-C水平比较,差异均无统计学意义(P＞0.05).相关分析和多元逐步回归分析结果显示,外周血单核细胞TLR4阳性率与LDL-C、TC呈正相关(P＜0.01);LDL和TC进入多元线性回归方程,是影响TLR4的危险因素.结论 哈萨克族原发性高血压患者外周血TLR4阳性率增高,TLR4阳性率与与血脂水平存在相关性.
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| 关 键 词： | 高血压病 哈萨克族 Toll样受体4 |
Expression of Peripheral Blood Mononuclear Cell TLR4 and Its Correlation in Essential Hypertension Patients in Xinjiang Kazakh |
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| DUAN Jun-cang,WANG Li,WANG Zhong,et al..Expression of Peripheral Blood Mononuclear Cell TLR4 and Its Correlation in Essential Hypertension Patients in Xinjiang Kazakh[J].Chinese General Practice,2011,14(9). |
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| Authors: | DUAN Jun-cang WANG Li WANG Zhong |
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| Institution: | DUAN Jun-cang,WANG Li,WANG Zhong,et al.Department of Cardiology,First Affiliated Hospital of Medical College of Shihezi University,Shihezi 832008,China |
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| Abstract: | Objective To explore the expression of Toll-like receptor 4(TLR4) in peripheral blood mononuclear cell(PBMC) and its relationship to blood lipid,blood glucose and obesity in patients with essential hypertension(EH) of Xinjiang Kazakh. Methods According to diagnostic criteria of hypertension,68 Kazakh EH patients were enrolled as EH group,70 healthy subjects as control.BP,height,weight,waist circumference(WC),hip circumference(HC) were measured,and fasting venous blood drawn to determine levels of fasting pl... |
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| Keywords: | Hypertension Kazakans TLR4 |
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