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| 子宫内膜癌和正常子宫内膜组织中Dickkopf-1表达及意义 | |
| 引用本文： | 伊诺,廖秦平,薛晓鸥,刘敏.子宫内膜癌和正常子宫内膜组织中Dickkopf-1表达及意义[J].中国全科医学,2011,14(9). |
| 作者姓名： | 伊诺 廖秦平 薛晓鸥 刘敏 |
| 作者单位： | 1. 首都医科大学附属北京地坛医院妇产科,北京市,100015 2. 北大医院妇产科 3. 北京中医药大学东直门医院妇科 |
| 摘 要： | 目的 检测Dickkopf-1在子宫内膜癌和正常子宫内膜组织中的表达,探讨Dickkopf-1表达与子宫内膜癌临床病理特征的关系以及在子宫内膜癌发生、发展中的作用.方法 采用免疫组化方法检测并比较Dickkopf-1在30例子宫内膜癌(内膜癌组)及34例正常子宫内膜(正常对照组)组织中的表达,并结合临床资料进行分析.结果 两组子宫内膜组织中Dickkopf-1的表达程度比较,差异有统计学意义(P＜0.05).子宫内膜癌不同手术病理分期、病理分级患者子宫内膜组织中的高表达率比较,差异有统计学意义(P＜0.05).子宫内膜癌不同病理类型、淋巴结是否转移患者子宫内膜组织中Dickkopf-1的高表达率比较,差异无统计学意义(P＞0.05).结论 Dickkopf-1表达与子宫内膜癌手术病理分期、病理分级有关联;Dickkopf-1表达改变可能与子宫内膜癌发生、发展有关,它有望成为临床上判断子宫内膜癌病程进展和预后的参考指标. |
| 关 键 词： | 子宫内膜肿瘤 子宫内膜 |
Expression of Dickkopf-1 in Endometrial Carcinoma and Normal Endometrial Tissues and Its Clinicopathological Significance |
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| YI Nuo,LIAO Qin-ping,XUE Xiao-ou,et al..Expression of Dickkopf-1 in Endometrial Carcinoma and Normal Endometrial Tissues and Its Clinicopathological Significance[J].Chinese General Practice,2011,14(9). | |
| Authors: | YI Nuo LIAO Qin-ping XUE Xiao-ou |
| Institution: | YI Nuo,LIAO Qin-ping,XUE Xiao-ou,et al.Department of Obstetrics and Gynecology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China |
| Abstract: | Objective To investigate the expression of Dickkopf-1 in endometrial carcinoma and benign endometrial tissues to explore its relationship to the clinicopathologic features of endometrial carcinoma. Methods Immunohistochemistry was conducted to detect the expression of Dickkopf-1 in 30 endometrial carcinoma samples(EC group) and 34 benign endometrium(BE group).The clinicopathologic features of endometrial carcinoma was analyzed. Results There was significant difference in Dickkopf-1 expression between 2 grou... |
| Keywords: | Dickkopf-1 |
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