Peri- and postoperative changes in serum levels of four tumor markers and three acute phase reactants in benign and malignant gynecological diseases |
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Authors: | E Åvall-Lundqvist K Sjövall L O Hansson P Eneroth |
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Institution: | (1) Department of Obstetrics and Gynecology, Clinical Research Center, Huddinge Hospital, S-104 01 Stockholm, Sweden;(2) Department of Clinical Chemistry, Karolinska Hospital, S-104 01 Stockholm, Sweden;(3) Unit for Applied Biochemistry, Clinical Research Center, Huddinge Hospital, S-104 01 Stockholm, Sweden |
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Abstract: | Summary Serum levels of squamous cell carcinoma antigen, carcinoembryonic antigen, CA 125, tissue polypeptide antigen, CRP, α1-antitrypsin and haptoglobin were determined peri- and postoperatively in patients undergoing surgery for benign gynecological
disease (n=18) and postoperatively in women operated for cervical carcinoma (n=23). The only significant changes seen after premedication, during anesthesia and during surgery were a decrease in serum
concentrations of α1-antitrypsin and haptoglobin. We found no post-operative changes in the serum levels of squamous cell carcinoma antigen nor
in carcinoembryonic antigen values. However, the latter analyte was influenced by smoking habits. Elevated levels of CA 125
and tissue polypeptide antigen were found in the cancer patients, predominantly within the first 1–3 weeks after surgery.
These levels decreased to normal values within 4–6 weeks postoperatively. The median intraindividual coefficients of variation
for the tumor markers ranged between 15% and 28% in 30 control women not having surgery. In general, it would seem advisable
to wait 6 weeks after surgery before monitoring with CA 125 and TPA is started. |
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Keywords: | Surgical trauma Tumor markers Acute phase reactants Gynecological disease |
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