Biosynthetic and proliferative characteristics of the prostatic epithelium in nodular hyperplasia,in cancer and in the peritumoral area

Close interaction between biosynthetic, proliferative and overall activities of nucleic acids in tumor epithelial cells, on the one hand, and histo-hematic barrier of peritumorous area, on the other, has been investigated. Nucleolar organizer regions in prostate cancer appeared very active and the interaction of histo-hematic barrier components much closer than in nodose hyperplasia. Fibroplastic and sclerotic alterations in stroma adjacent to tumor enhanced. It is significant that profound changes occur in the epithelium-connective tissue system in prostate cancer regions which are morphologically identical with those in nodose hyperplasia. It is suggested that such changes might accompany tumorigenesis as well as precede it. In either situation, said characteristics of histo-hematic barrier of peritumorous area may be instrumental in early detection of prostate cancer, particularly, when puncture biopsies are used.