| 吡哌酸锌对实验性胃溃疡的保护作用 |
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| 引用本文： | 刘春霞,尹志奎,刘晓丽,杨玉亭,刘巨源,张小毅.吡哌酸锌对实验性胃溃疡的保护作用[J].新乡医学院学报,2000,17(4):240-241,244. |
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| 作者姓名： | 刘春霞 尹志奎 刘晓丽 杨玉亭 刘巨源 张小毅 |
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| 作者单位： | 新乡医学院药理教研室,河南,新乡,453003 |
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| 摘 要： | 目的 探讨吡哌酸锌对实验性胃溃疡的作用及作用机制。方法 健康大鼠和小鼠 ,均衡随机分为 5组 ,即阴性对照组 (羧甲基纤维素钠 )、阳性对照组 (西咪替丁 )、吡哌酸锌 2 5mg·kg-1、5 0mg·kg-1和10 0mg·kg-1剂量组 (小鼠剂量加倍 ) ,每组 10只 ,分别观察对 4种实验性胃溃疡的作用。结果 吡哌酸锌对各种胃溃疡模型的抑制率与阴性对照组相比差异显著 (P <0 .0 1) ,并呈剂量依赖性。结论 吡哌酸锌对实验性胃溃疡有保护作用。
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| 关 键 词： | 吡哌酸锌 实验性胃溃疡 西咪替丁 小鼠 大鼠 |
| 文章编号： | 1004-7239(2000)04-0240-02 |
Protective effects of zinc pipemidate on experimental gastric ulcers |
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| LIU Chun- xia,YIN Zhi-kui,YANG Yu-ting,et al.Protective effects of zinc pipemidate on experimental gastric ulcers[J].Journal of Xinxiang Medical College,2000,17(4):240-241,244. |
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| Authors: | LIU Chun- xia YIN Zhi-kui YANG Yu-ting |
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| Abstract: | Objective To study the effects of zinc pipemidate on experimental gastric ulcers and its mechanism.Methods Normal rats and mice were randomly dirvided into 5 groups including negative control group(sodium carboxymethyl cellulose),positive control group(cimetidine),groups of zinc pipemidate(25mg·kg -1 ,50mg·kg -1 and 100mg·kg -1 ) in rat (50mg·kg -1 ,100mg·kg -1 and 200mg·kg -1 groups in mice).Each group included 10 animals. The effects of zinc pipemidate on experimental gastric ulcers were observed . Results Zine pipemidate produced dose-dependent relationship and significance hibitory effects on gastric ulcers, compared with the control group . Conclusion Zinc pipemidate pressesses protective effects on experimental gastric ulcer. |
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| Keywords: | zinc pipemidate experimental gastric ulcer cimetidine protective effect rat mice |
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