Pharmacokinetics of intravenous propafenone in patients with episodes of paroxysmal supraventricular tachycardia

The plasma concentration time curves of propafenone after administration of single i.v. (2.3 +/- 0.2 mg/kg) doses have been studied in ten patients undergoing an electrophysiological study to evaluate episodes of recurrent supraventricular tachycardia. The propafenone kinetics profile can be described by a two-compartment open model. Mean values of main variables were t 1/2 alpha = 2.8 min, t 1/2 beta = 80 min, Kel = 0.12 min, -1, Vd beta = 1.6 1/kg, Cl = 1.03 1/h and AUR = 3.1 mg/h-1.