Prospects for neural stem cell-based therapies for neurological diseases |
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Authors: | Jaime Imitola |
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Institution: | 1. Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, 02115, Boston, Massachusetts
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Abstract: | Neural stem and progenitor cells have great potential for the treatment of neurological disorders. However, many obstacles
remain to translate this field to the patient’s bedside, including rationales for using neural stem cells in individual neurological
disorders; the challenges of neural stem cell biology; and the caveats of current strategies of isolation and culturing neural
precursors. Addressing these challenges is critical for the translation of neural stem cell biology to the clinic. Recent
work using neural stem cells has yielded novel biologic concepts such as the importance of the reciprocal interaction between
neural stem cells and the neurodegenerative environment. The prospect of using transplants of neural stem cells and progenitors
to treat neurological diseases requires a better understanding of the molecular mechanisms of both neural stem cell behavior
in experimental models and the intrinsic repair capacity of the injured brain. |
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