DNA ploidy pattern in rectal carcinoid tumors |
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Authors: | Dr. George Tsioulias M.D. Tetsuihiro Muto M.D. D.Sc. Yoshiro Kubota M.D. Tadahiko Masaki M.D. Kimitaka Suzuki M.D. Takayuki Akasu M.D. Yasuhiko Morioka M.D. |
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Affiliation: | (1) 1st Department of Surgery, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113 Tokyo, Japan |
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Abstract: | The nuclear DNA pattern of 22 rectal carcinoids was determined by cytophotometry of paraffin embedded tissues. The results were compared with clinical as well as histopathologic features of the tumor. Three of the carcinoids with synchronous or metachronous metastasis had aneuploid DNA pattern, whereas 19 tumors with no metastasis showed diploid DNA pattern. No other single clinical or pathologic feature of the tumor could predict more accurately the malignant potential and the subsequent course of the rectal carcinoid. It is concluded that DNA aneuploidy in rectal carcinoid tumors is not so rare as indicated by earlier studies and that it is a factor of significant prognostic value.Dr. George Tsioulias is a recipient of the Monbusho Scholarship (Japanese Ministry of Education). |
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Keywords: | Rectal carcinoid tumor DNA ploidy |
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