Sphenoid Sinus Basaloid Squamous Cell Carcinoma Presenting as a Sellar Mass: Report a Case with Review of the Literature |
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Authors: | Xin Gu Farzan Eskandari Marjorie Fowler |
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Institution: | (1) Department of Pathology, Louisiana State University Health Science Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA |
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Abstract: | Basaloid squamous cell carcinoma (BSCC) is a distinctive variant of squamous cell carcinoma (SCC) with more aggressive behavior.
It occurs preferentially in the upper aerodigestive tract. Sinonasal tract BSCC is uncommon, and only limited studies have
been reported in literature. In these studies, most BSCCs arose from the nasal mucosa with or without extension to the paranasal
sinuses. Rare reported cases of BSCC involved only the paranasal sinus. In this report, we present a case of a female patient
with a sphenoid sinus mass. Clinically, the patient had progressively decreasing vision and headache. Magnetic resonance imaging
(MRI) and computerized tomographic (CT) scan showed an infiltrating tumor mass involving the sphenoid sinus and the sella
with compression of the optic nerve. Pathologic examination revealed an invasive basaloid epithelial neoplasm that was arranged
in lobules, nests and cords. The tumor also showed palisading of peripheral cells, focal abrupt squamous differentiation and
in situ carcinoma in the surface mucosa. In the immunohistochemical studies, this tumor revealed a strongly positive nuclear
staining for p63. The morphologic and ancillary studies indicated a BSCC. To the best of our knowledge, this is the first
report of sinonasal tract BSCC that mainly involved the sphenoid bone and sella. In this region, BSCC should be distinguished
from benign and malignant neoplasms that more often affect sella and base of skull, such as pituitary adenoma with extensive
necrosis, small cell neuroendocrine carcinoma (SCNC), olfactory neuroblastoma, malignant germ cell tumor, paranasal adenoid
cystic carcinoma (ACC), and a variety of metastatic malignancies. |
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Keywords: | Basaloid squamous cell carcinoma Sphenoid sinus Sellar mass |
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