| 小鼠暂时性脑缺血引起学习记忆障碍模型的制备及人参皂甙的保护作用 |
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| 引用本文： | 裘月,杜冠华,屈志炜,张均田.小鼠暂时性脑缺血引起学习记忆障碍模型的制备及人参皂甙的保护作用[J].中国药理学通报,1995(4). |
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| 作者姓名： | 裘月 杜冠华 屈志炜 张均田 |
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| 作者单位： | 中国医学科学院，中国协和医科大学药物研究所 |
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| 摘 要： | 人参皂甙是人参的主要有效成分。本文在建立小鼠脑缺血再灌注导致学习记忆障碍模型的基础上，用跳台、避暗两种实验方法观察了人参皂甙对小鼠脑缺血再灌注后学习记忆功能的保护作用。结果显示小鼠脑缺血再灌注可以导致学习记忆障碍，而人参皂甙（１０，１００ｍｇ·ｋｇ－１，ｐｏ）可以对这种记忆障碍起到保护作用。
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| 关 键 词： | 人参皂甙 脑缺血再灌注 学习 记忆 |
Protective effects of ginsenoside on the learning and memory impairment induced by transient cerebral ischemia-reperfusion in mice |
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| QIU Yue, DU Guan-Hua, QU Zhi-Wei,ZHANG Jun-Tian.Protective effects of ginsenoside on the learning and memory impairment induced by transient cerebral ischemia-reperfusion in mice[J].Chinese Pharmacological Bulletin,1995(4). |
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| Authors: | QIU Yue DU Guan-Hua QU Zhi-Wei ZHANG Jun-Tian |
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| Abstract: | The effects of ginsenoside,the major component of ginsen,on the learning and memory impairment induced by transient cerebral ischemia-reperfusion was studied by means of step down test and step through test in mice.The result indicated that transient cerebral ischemia-reperfusion could induce learning and memory impairment in mice. While ginsenoside(10 mg·kg-1,100 mg·kg-1,po) could protect the learning and memory function from the in jury. |
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| Keywords: | ginsenoside cerebral ischemia-reperfusion learning memory |
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