首页 | 本学科首页   官方微博 | 高级检索  
检索        


Modification of L-DOPA pharmacological activity by MAO inhibitors
Authors:J P M Finberg  O Sader-Mazbar
Institution:(1) Pharmacology Department, Rappaport Faculty of Medicine, Technion, Haifa, Israel
Abstract:Summary Dopamine behaves mainly as a MAO-A substrate in rodent brain, but selective inhibition of MAO-B results in an increased turning activity following L-DOPA administration in hemi-Parkinsonian rodents. Unilateral substantia nigra dopaminergic denervation results in serotonergic hyper-innervation which may increase the contribution of MAO-A in the denervated striatum. Possibly as a result of this, there was no change in striatal MAO-A activity when 95% of dopaminergic innervation was reduced by 6-hydroxydopamine, as assessed by apomorphine-induced turning activity. MAO-B as well as MAO-A may contribute to deamination of dopamine produced from L-DOPA.
Keywords:: Dopamine  6-hydroxydopamine  5-hydroxytryptamine  5  7-dihydroxytryptamine  hemi-Parkinsonian rat model  aromatic          amino-acid decarboxylase
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号