| 精神分裂症免疫发病机制的探讨 |
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| 引用本文： | 倪传源,陈湘绮,夏家珍,徐冰,徐虹,许桦,齐名,何家声,任昌庭.精神分裂症免疫发病机制的探讨[J].东南大学学报(医学版),1985(1). |
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| 作者姓名： | 倪传源 陈湘绮 夏家珍 徐冰 徐虹 许桦 齐名 何家声 任昌庭 |
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| 作者单位： | 南京铁道医学院科研所免疫室，南京铁道医学院科研所免疫室，南京铁道医学院科研所免疫室，南京铁道医学院科研所免疫室，南京铁道医学院科研所免疫室，南京铁道医学院科研所免疫室，南京铁道医学院科研所免疫室，南京铁道医学院精神神经病学教研室，安徽滁县地区第一医院精神科 |
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| 摘 要： | 本文通过对44例精神分裂症患者免疫状态多方面的观察和研究,证实患者T细胞数和PHA刺激的LTT降低,IgG、IgA和IgM含量增加,CH_(50)、C_3、C_4减少,而AP-CH_(50)增高,与健康对照组比较差异有高度显著性。17例患者血中出现C_3DP,26例患者CIC阳性,6例ANA阳性。ATA水平增高,与健康对照组比较差异有高度显著性。认为CIC通过传统途径激活补体在本病发病机制中起重要作用;ATA并不是本症的特异因子,它的增高可能类似患者其他一些生物学现象,但这些因素结合在一起就有可能造成脑组织损伤,因此ATA水平高的健康人发生精神分裂症的机会可能要比ATA水平正常的人为多。
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| 关 键 词： | 精神分裂症—发病机制 免疫检测 循环免疫复合物 抗胸腺细胞抗体 |
STUDY ON MECHANISM OF IMMUNE IN SCHIZOPHRENIA |
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| Ni Chuanyuan Chen Xiangqi Xia jiazhen Xu Bing Xu Hong Xu Hua Qi Ming He Jiasheng Ren Chanting.STUDY ON MECHANISM OF IMMUNE IN SCHIZOPHRENIA[J].Journal of Southeast Univ: Medical Sci Ed,1985(1). |
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| Authors: | Ni Chuanyuan Chen Xiangqi Xia jiazhen Xu Bing Xu Hong Xu Hua Qi Ming He Jiasheng Ren Chanting |
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| Institution: | Ni Chuanyuan Chen Xiangqi Xia jiazhen Xu Bing Xu Hong Xu Hua Qi Ming He Jiasheng Ren Chanting |
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| Abstract: | The observations on immune condition in 44 cases of schizophrenia showed that T lympocyte and LTT (stimulated PHA) decreased; IgG, IgA and IgM increased;CH_50,C_3 and C_4 reduced and APCH_50 rose.C_3DP was found in 17 cases, CIC was positive in 26 and ANA in 6. ATA increased markedly in the patients,It is considered that CIC plays an important role in the pathogenesis of the disease to activate complement through classical pathway.ATA isn't a specific factor for schizophrenia, but may be one of the factors resulting in injury of brain tissue.Therefore the possibility of suffering from the disease is larger in health individuals whose ATA increase than in those normal. |
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| Keywords: | shizophrenia-pathogenesis immunoassay circulating immune complex anti-thymocyte antibody |
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