不同剂量的氟比洛芬酯用于甲状腺手术超前镇痛

目的观察不同剂量的氟比洛芬酯对甲状腺手术病人的超前镇痛效果。方法对80例双侧甲状腺次全切除术的病人随机双盲分为4组,在静脉诱导前5 min静脉注射。Ⅰ组给予氟比洛芬酯1.25 mg/kg;Ⅱ组氟比洛芬酯1.0 mg/kg;Ⅲ组氟比洛芬酯0.75 mg/kg,Ⅳ组空白对照。术后2、4、8、16、24、48 h,用视觉模拟评分(VAS)评价吞咽时疼痛,舒适评分(BCS)评价咳嗽时疼痛,并记录不良反应。结果 VAS:2、4、8、16 h时,Ⅰ、Ⅱ、Ⅲ组显著低于Ⅳ组(P<0.01),24、48 h时,Ⅰ、Ⅱ组显著低于Ⅳ组(P<0.01),Ⅲ组与Ⅳ组无显著差异(P>0.05)。BCS2、4、8、16 h时,Ⅰ、Ⅱ、Ⅲ组显著优于Ⅳ组(P<0.05)。本文4组不良反应无显著差异(P>0.05)。结论 1.0 mg/kg、1.25 mg/kg组氟比洛芬酯用于甲状腺手术超前镇痛安全有效,且1.0 mg/kg、1.25 mg/kg组氟比洛芬酯可延长镇痛时间。

Preemptive Analgesic Effect of Different Dose Flurbiprofen Axetil in Subtotal Thyroidectomy

Objective To study the preemptive analgesic effect of flurbiprofen axetil with different dose used in subtotal thyroidectomy.Methods Eighty patients undergoing thyroid diseases were randomly divided into four groups（20 patients per group）.Every group received intravenous injection 5 min before the intravenus induction.Group Ⅰ received flurbiprofen axetil 1.25 mg/kg,group Ⅱ received 1.0 mg/kg,group Ⅲ received 0.75 mg/kg,and group Ⅳ（control group） did not receive any analgesic.We used visual analogue scale（VAS） and Bruggrmann comfort scale（BCS） to assess swallowing pain and cough pain separately at 2,4,8,16,24 and 48 h after operation.Adverse effects were recorded.Results VAS at 2,4,8,16 h,groupⅠ,Ⅱ and Ⅲ were significantly lower than group Ⅳ（P0.01）,and at 24,48 h,groupⅠand Ⅱ were significantly lower than group Ⅳ（P0.01）while there were no significant differences between group Ⅲ and group Ⅳ（P0.05）.BCS at 2,4,8,16 h,groupⅠ,Ⅱand Ⅲ were significantly higher than group Ⅳ（P0.05）.There were no significant differences among four groups in adverse effects.Conclusions The doses of Flurbiprofen axetil 1.0 mg/kg and 1.25 mg/kg might be safe and effective in preemptive analgesic of subtotal thyroidectomy.The dose of 1.25 mg/kg could prolong the analgesic time.