| 参三七皂甙Rg1对实验性血栓形成的影响及其机制探讨 |
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| 引用本文： | 徐皓亮,刘宛斌,饶曼人.参三七皂甙Rg1对实验性血栓形成的影响及其机制探讨[J].药学学报,1997,32(7):502-505. |
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| 作者姓名： | 徐皓亮 刘宛斌 饶曼人 |
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| 作者单位： | 南京医科大学心血管药理研究室 |
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| 摘 要： | 用大鼠动静脉血栓形成模型,研究参三七皂甙Rg1抗血栓作用。结果表明,参三七皂甙Rg1可明显降低实验性血栓形成,对大鼠血浆纤溶系统亦有明显作用,可升高血浆中组织纤溶酶原激活物(t-PA)活性和活性型t-PA百分比,降低组织纤溶酶原激活物抑制剂(PAI)活性。同时利用培养大鼠血管内皮细胞实验,发现Rg1可以剂量依赖性提高血管内皮细胞一氧化氮(NO)释放。提示Rg1抗血栓作用与增强纤溶系统活性,促进血管内皮NO释放有关。
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| 关 键 词： | 参三七皂甙Rg1 血栓形成 组织纤溶酶原激活物 纤溶酶原激活物抑制剂 一氧化氮 |
| 收稿时间： | 1996-08-24 |
EFFECT OF SANCHINOSIDE Rg1 ON EXPERIMENTAL THROMBOSIS AND ITS MECHANISMS |
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| HL Xu,WB Liu and MR Rao.EFFECT OF SANCHINOSIDE Rg1 ON EXPERIMENTAL THROMBOSIS AND ITS MECHANISMS[J].Acta Pharmaceutica Sinica,1997,32(7):502-505. |
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| Authors: | HL Xu WB Liu and MR Rao |
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| Abstract: | The effect of sanchinoside Rg1 on generation of thrombosis and its mechanism was studied. Rg1 was shown to markedly inhibit experimental thrombosis formation induced by extra corporeal shunt between the carotid artery and jugular vein. After Rg1 infusion, the activity of t-PA was found to be increased, so did the percentage of active-type t-PA, but the activity of PA-I decreased.Further data in our study indicate that incubation of endothelial cells with Rg1 for 24 h caused significant increase of NO production. This effect was found to be dose-dependent.These observations suggest that Rg1 is a potent anti-thrombosis substance and can enhance the function of fibrinolysis system and stimulate vascular endothelial cells to release NO. |
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| Keywords: | Thombosis Tissue-plasminogen activator Plasminogen activator inhibitor Nitric oxide Sanchinoside Rg1 |
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