| 米非司酮与皮质醇合用对大鼠睾丸间质细胞分泌睾酮的影响 |
| |
| 引用本文： | 张莉 杜松洁. 米非司酮与皮质醇合用对大鼠睾丸间质细胞分泌睾酮的影响[J]. 中国计划生育学杂志, 2000, 8(12): 538-540 |
| |
| 作者姓名： | 张莉 杜松洁 |
| |
| 作者单位： | [1]中国医学科学院中国协和医科大学药物研究所药理室,北京 [2]中国医学科学院中国协和医科大学药物研究所药理室,北 |
| |
| 摘 要： | 为研究米非司酮和皮质醇对大鼠睾丸间质细胞(Leydig Cells)的睾酮基础分泌及促性腺激素刺激睾酮分泌的影响,将雄性大鼠处死,取睾丸间质细胞进行体外培养,用放射免疫分析方法测定睾酮含量。实验结果显示米非司酮抑制睾酮的基础分泌,而皮质醇对其无影响;两药单独使用时,均抑制促性腺激素刺激的睾酮分泌,合用有协同作用。本研究表明米非司酮和皮质醇均能影响睾丸的甾体激素的合成。
|
| 关 键 词： | 米非司酮 皮质醇 睾酮 间质细胞 |
Effect of Combination of Mifepristone with Cortisol on the Testosterone Production of Rat Leydig Cells in Vitro. |
| |
| Abstract: | Objectives:To investigate the effect of mifepristone and cortisol on basal or hCG-stimulated testosterone production. Methods : Adult Wistar rats were sacrificed and Leydig cells collected for incubation with mifepristone, cortisol and hCG. T levels in culfurals was measured by radioim-munoassay. Results: Incubation with mifepristone decreased basal T production in a dose-dependent manner,but cortisol didn't affected it,Both mifepristone and cortisol inhibited hCG-stimulated T production and they have synergism. Conclusions : These data suggested that cortisol play an important role in the testicular steroidgenesis. mifepristone and cortisol were found to have a direct effect on testosterone production of Leydig cells in rats. |
| |
| Keywords: | Mifepristone Cortisol Testosterone Leydig cells |
| 本文献已被 维普 等数据库收录！ |
|
