| 乙双吗啉的致突变作用 |
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| 引用本文： | 陈森清,薛开先,吴建中,马国建. 乙双吗啉的致突变作用[J]. Acta pharmacologica Sinica, 1995, 0(6) |
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| 作者姓名： | 陈森清 薛开先 吴建中 马国建 |
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| 作者单位： | 江苏省肿瘤防治研究所，江苏省肿瘤防治研究所，江苏省肿瘤防治研究所，江苏省肿瘤防治研究所 南京 210009 中国，南京 210009 中国，南京 210009 中国，南京 210009 中国 |
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| 摘 要： | 目的:研究乙双吗啉的遗传毒性.方法:乙双吗啉5,10和15 mg·kg~(-1),腹腔注射观察诱发的小鼠骨髓染色体/染色单体畸变;应用Ames试验观察对测试菌株TA97,TA98,TA100,TA102的诱变作用.结果:乙双吗啉显著诱发小鼠骨髓染色体/染色单体畸变,其诱发的畸变细胞率(ACF)显著增加(P<0.01);在不加S9条件下,乙双吗啉对TA98,TA102有一定的诱发回复突变的作用.结论:乙双吗啉是一种遗传毒物质.
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| 关 键 词： | 乙双吗啉 诱变性试验 染色体畸变 骨髓 |
Mutagenic effects of bimolane |
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| CHEN Sen-Qing,XUE Kai-Xian,WU Jian-Zhong. MA Guo-Jian. Mutagenic effects of bimolane[J]. Acta pharmacologica Sinica, 1995, 0(6) |
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| Authors: | CHEN Sen-Qing XUE Kai-Xian WU Jian-Zhong. MA Guo-Jian |
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| Abstract: | To study the genotoxicity of bimolane. METHODS:Bimolane 5, 10, and 15 mg .kg-1 was injected ip in mice to investigate its effects on chromosome/chromatid aberrations of bone marrow cells. Mutagenic effects on TA97, TA98, TA100, TA102 were studied in Ames test. RESULTS: Bimolane 5, 10, and 15 mg . kg-1 induced of chromosome/chromatid aberrations, and the frequency of aberration cells (ACF) induced by bimolane increased markedly (F<0. 01); Bimolane without S9 showed mutagenic to TA98 and TA102 at the concentrations of 100 and 150ug/plate in Ames test. CONCLUSION: Bimolane is a kind of genotoxic compound. |
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| Keywords: | bimolane mutagenicity tests chromosome aberrations bone marrow |
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